Abstract
Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
MeSH terms
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Acetamides / adverse effects*
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Acetamides / pharmacology
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Acidosis, Lactic / blood
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Acidosis, Lactic / chemically induced*
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Adolescent
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / pharmacology
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Fatal Outcome
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Female
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Humans
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Infant
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Lactic Acid / blood*
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Linezolid
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Male
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Mitochondria / drug effects
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Mitochondria / metabolism
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Oxazolidinones / adverse effects*
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Oxazolidinones / pharmacology
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Lactic Acid
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Linezolid