Abstract
We describe 2 cases in which the prolonged use of linezolid to treat complicated methicillin-resistant Staphylococcus aureus infections was followed by acutely developed blurred vision and progressive loss of vision and color perception during the ensuing few weeks. Both patients received a diagnosis of toxic optic neuropathy, and linezolid therapy was stopped. The patients experienced an initial rapid partial improvement and a subsequent gradual, almost complete, recovery over many months.
MeSH terms
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Acetamides / adverse effects*
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Acetamides / therapeutic use
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Aged
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Anti-Infective Agents / adverse effects*
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Anti-Infective Agents / therapeutic use
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Female
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Humans
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Linezolid
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Male
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Methicillin Resistance
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Middle Aged
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Optic Nerve Diseases / chemically induced*
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Optic Nerve Diseases / physiopathology
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Oxazolidinones / adverse effects*
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Oxazolidinones / therapeutic use
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Staphylococcal Infections / drug therapy
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Staphylococcus aureus / drug effects
Substances
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Acetamides
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Anti-Infective Agents
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Oxazolidinones
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Linezolid