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Leukoreduction to prevent complications of blood transfusion

Arthur J Silvergleid, MD
Section Editor
Steven Kleinman, MD
Deputy Editor
Jennifer S Tirnauer, MD


Leukocytes, which are naturally collected along with other cellular elements in a whole blood collection, are considered a contaminant of other cellular blood components (red blood cells [RBCs] and platelets) and have increasingly been recognized as a contributor to, if not the cause of, a number of adverse consequences of blood transfusion:

Immunologically mediated effects

Infectious disease transmission

Reperfusion injury

Immunologically mediated effects are by far the most common, including:

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Literature review current through: Nov 2017. | This topic last updated: Sep 25, 2017.
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