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Medline ® Abstract for Reference 51

of 'Juvenile idiopathic arthritis: Epidemiology and immunopathogenesis'

Association of HLA-Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the "shared epitope" hypothesis.
Willkens RF, Nepom GT, Marks CR, Nettles JW, Nepom BS
Arthritis Rheum. 1991;34(1):43.
Rheumatoid arthritis (RA) is prevalent in Yakima Indians, a Native American tribe. HLA-DR4, the HLA specificity commonly associated with RA in Caucasians, is rare among the Yakima. Using a specific oligonucleotide probe that recognizes DR4 nucleotide sequences associated with RA, a rare HLA-Dw16 gene was identified in 83% of Yakima patients with RA and in 60% of Yakima control subjects. This shared sequence encodes a discrete class II epitope that is highly correlated with RA in both DR4 positive and DR4 negative individuals.
Harborview Medical Center, Seattle, WA 98104.