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Medline ® Abstract for Reference 153

of 'Juvenile idiopathic arthritis: Epidemiology and immunopathogenesis'

Enhanced interleukin 1 and depressed interleukin 2 production in juvenile arthritis.
Martini A, Ravelli A, Notarangelo LD, Maccario R, Lanfranchi A, Rondena D, Ugazio AG, Burgio R
J Rheumatol. 1986;13(3):598.
Blood mononuclear cells from a total of 23 children with juvenile arthritis were stimulated in vitro to produce interleukin 1 (IL-1) and interleukin 2 (IL-2) and compared with age matched healthy controls. Peripheral blood monocytes from patients with juvenile arthritis produced a higher amount of IL-1 than controls, whereas peripheral blood lymphocytes from the same patients produced lower amount of IL-2 than controls. These findings could not be explained by concurrent therapy. The increase of IL-1 production was more marked in patients with active disease and therefore may have been secondary to the pathological process. However, the decrease of IL-2 production did not depend on disease activity, thus suggesting an immunoregulatory abnormality.