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Medline ® Abstract for Reference 130

of 'Juvenile idiopathic arthritis: Epidemiology and immunopathogenesis'

Antigen specificity of gamma delta T lymphocytes.
Born WK, O'Brien RL, Modlin RL
FASEB J. 1991;5(12):2699.
gamma delta T cells represent a new lymphocyte subset without a definitive functional assignment. Although in many ways similar to alpha beta T lymphocytes, they are clearly distinguished by their expression of a different set of T cell receptor genes, a different distribution in normal tissues, and perhaps also different ligand specificities. Because gamma delta T cells appear to be involved in a variety of human diseases, the determination of their biological role has become an important challenge for immunologists and researchers in related areas.
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.