Abstract
Isotretinoin is considered to be a safe and effective therapy in otherwise therapy-resistant acne. Elevated serum creatine phosphokinase values with or without muscle-related symptoms in isotretinoin-treated patients have been reported and interpreted as benign phenomena, lethal cases have not been described yet. We present the case of a 20-year-old male who died from severe generalised rhabdomyolysis associated with isotretinoin treatment.
MeSH terms
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Acne Vulgaris / drug therapy*
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Administration, Oral
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Administration, Topical
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Dermatologic Agents / administration & dosage
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Dermatologic Agents / toxicity*
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Dose-Response Relationship, Drug
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Drug Substitution
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Fatal Outcome
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Humans
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Isotretinoin / toxicity*
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Long-Term Care
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Lung / pathology
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Male
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Muscle, Skeletal / pathology
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Necrosis
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Phagocytosis / physiology
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Pulmonary Edema / chemically induced
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Pulmonary Edema / pathology
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Rhabdomyolysis / chemically induced*
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Rhabdomyolysis / pathology*
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Ventricular Fibrillation / chemically induced
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Ventricular Fibrillation / pathology
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Young Adult
Substances
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Dermatologic Agents
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Isotretinoin