Abstract
We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.
MeSH terms
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Adult
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Alcoholism / complications*
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Anticonvulsants / therapeutic use
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Antitubercular Agents / adverse effects*
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Humans
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Isoniazid / adverse effects*
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Male
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Pyridoxine / therapeutic use
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Risk Factors
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Seizures / chemically induced*
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Seizures / diagnosis
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Seizures / drug therapy
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Smoking / adverse effects*
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Treatment Outcome
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Tuberculosis, Pulmonary / diagnosis
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Tuberculosis, Pulmonary / drug therapy*
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Tuberculosis, Pulmonary / microbiology
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Vitamin B Complex / therapeutic use
Substances
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Anticonvulsants
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Antitubercular Agents
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Vitamin B Complex
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Pyridoxine
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Isoniazid