Isoniazid induced convulsions at therapeutic dose in an alcoholic and smoker patient

Curr Drug Saf. 2015;10(1):94-5. doi: 10.2174/1574886309666140930151343.

Abstract

We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alcoholism / complications*
  • Anticonvulsants / therapeutic use
  • Antitubercular Agents / adverse effects*
  • Humans
  • Isoniazid / adverse effects*
  • Male
  • Pyridoxine / therapeutic use
  • Risk Factors
  • Seizures / chemically induced*
  • Seizures / diagnosis
  • Seizures / drug therapy
  • Smoking / adverse effects*
  • Treatment Outcome
  • Tuberculosis, Pulmonary / diagnosis
  • Tuberculosis, Pulmonary / drug therapy*
  • Tuberculosis, Pulmonary / microbiology
  • Vitamin B Complex / therapeutic use

Substances

  • Anticonvulsants
  • Antitubercular Agents
  • Vitamin B Complex
  • Pyridoxine
  • Isoniazid