What makes UpToDate so powerful?

  • over 11000 topics
  • 22 specialties
  • 5,700 physician authors
  • evidence-based recommendations
See more sample topics
Find Print
0 Find synonyms

Find synonyms Find exact match

Initial management of trauma in adults
Official reprint from UpToDate®
www.uptodate.com ©2017 UpToDate, Inc. and/or its affiliates. All Rights Reserved.
The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The use of this website is governed by the UpToDate Terms of Use ©2017 UpToDate, Inc.
Initial management of trauma in adults
View in Chinese
All topics are updated as new evidence becomes available and our peer review process is complete.
Literature review current through: Nov 2017. | This topic last updated: Oct 30, 2017.

INTRODUCTION — Traumatic injuries can range from minor isolated wounds to complex injuries involving multiple organ systems. All trauma patients require a systematic approach to management to maximize outcomes and reduce the risk of undiscovered injuries.

This review will discuss the initial management of adult trauma patients. The management of pediatric trauma patients and specific injuries are reviewed separately. (See "Trauma management: Approach to the unstable child" and "Trauma management: Unique pediatric considerations" and "Initial evaluation of shock in the adult trauma patient and management of NON-hemorrhagic shock".)

EPIDEMIOLOGY — Trauma is a leading cause of mortality globally [1]. Worldwide, road traffic injuries are the leading cause of death between the ages of 18 and 29, while in the United States, trauma is the leading cause of death in young adults and accounts for 10 percent of all deaths among men and women [2]. Over 45 million people sustain moderate to severe disability each year due to trauma [1]. In the United States alone, more than 50 million patients receive some form of trauma-related medical care annually, and trauma accounts for approximately 30 percent of all intensive care unit (ICU) admissions [3,4].

According to the World Health Organization (WHO), road traffic injuries accounted for 1.25 million deaths in 2014, and trauma is expected to rise to the third leading cause of disability worldwide by 2030 [1,5]. Outside areas of armed conflict, penetrating injuries are responsible for fewer than 15 percent of traumatic deaths worldwide [6], but these rates vary by country. As examples, while homicide accounts for as many as 45 percent of deaths in Los Angeles, penetrating injuries account for only 13 percent of deaths in Norway [7]. Approximately half of traumatic deaths result from central nervous system (CNS) injury, while a third result from exsanguination [8].

Patients with serious traumatic injuries have a significantly lower likelihood of mortality or morbidity (10.4 versus 13.8 percent; relative risk [RR] 0.75, 95% CI 0.60-0.95) when treated at a designated trauma center [9]. Older age, obesity, and major comorbidities are associated with worse outcomes following trauma [10-18]. In trauma patients with significant hemorrhage, a lower score on the Glasgow Coma Scale (GCS) and older age are both independently associated with increased mortality, according to multivariable logistic regression analysis of two large databases [19]. In a large retrospective study from the United States National Trauma Data Bank, warfarin use was associated with an approximately 70 percent increased risk of mortality following trauma, after adjusting for other important risk factors (odds ratio [OR] 1.72; 95% CI 1.63-1.81) [20].

While the most common causes of mortality from trauma are hemorrhage, multiple organ dysfunction syndrome, and cardiopulmonary arrest [21], the most common preventable causes of morbidity are unintended extubation, technical surgical failures, missed injuries, and intravascular catheter-related complications [22].

Relatively few patients die after the first 24 hours following injury. Rather, the majority of deaths occur either at the scene or within the first four hours after the patient reaches a trauma center [23,24].

The "golden hour" concept, which emphasized the increased risk of death and the need for rapid intervention during the first hour of care following major trauma, was described in early trauma studies and has been promulgated in textbooks and instructional courses [25]. Undoubtedly, there are instances when rapid intervention improves the outcome of injured patients (eg, obstructed airway, tension pneumothorax, severe hemorrhage), especially in battlefield injuries [26]. However, the relationship between timing and mortality may be more complex than once thought. In a large study using registries from multiple trauma centers across North America, no association between emergency medical services (EMS) intervals (eg, on scene and transport times) and trauma patient mortality was found [27,28].

MECHANISM — Particular mechanisms predispose patients to specific injuries. Common blunt trauma mechanisms and their most frequently associated injuries are described in the accompanying table (table 1). In addition, certain high-risk blunt mechanisms, including pedestrians struck by automobiles, motorcycle accidents, severe motor vehicle accidents (eg, extensive damage leading to prolonged extrication time), and falls greater than 20 feet, have been associated with greater morbidity and mortality [29-32].


Pre-arrival preparation — Whenever possible, emergency medical services (EMS) should notify the receiving hospital that a trauma patient is en route. This provides the receiving hospital with information and time that can be crucial to the management of the severely injured patient.

Ideally, the information provided by EMS includes:

Patient age and sex

Mechanism of injury

Vital signs (some clinicians ask for the lowest blood pressure and highest pulse)

Apparent injuries

Early notification enables emergency department (ED) staff to do the following:

Notify additional personnel (eg, ED staff, trauma surgery, obstetrics, orthopedics, radiology, interpreter services)

Assure resources are available (eg, ultrasound, CT, operating room space)

Prepare for anticipated procedures (eg, tracheal intubation, chest tube)

Prepare for blood transfusion

In addition, information provided by EMS prior to arrival can help hospital-based clinicians focus on more likely injuries (table 1). As an example, a description of a feet-first fall from great height raises suspicion for fractures of the calcaneus, lower extremity, and lumbar spine; similarly, report of a prolonged motor vehicle extrication due to collapse of the driver's side compartment raises concern for injuries such as rib fractures, pulmonary contusion, and lacerations of the spleen and kidney.

Universal precautions against blood and fluid borne diseases should be part of the trauma team's preparation. These include gloves, gowns, masks, and eye protection for all members of the team involved in the resuscitation. Lead shields for staff should be available if portable x-rays are to be performed during resuscitation efforts.

Trauma team — In rural hospitals, the trauma team may be limited to one physician and a nurse. In such settings, the team might enlist help from EMS personnel or other clinicians to manage critically ill or multiple patients. Teams at major trauma centers may include emergency physicians, trauma surgeons, subspecialist surgeons, emergency nurses, respiratory therapists, technicians, and social workers. Regardless of the setting, all teams must have a clearly designated leader who determines the overall management plan and assigns specific tasks. While leaders of smaller teams might find themselves having to perform procedures in order to care effectively for their patients, leaders of larger teams should avoid performing procedures. This allows the leader to remain focused on their supervisory responsibilities and on the patient and possible changes in their condition.

Regardless of setting or team composition, optimal care of a trauma patient requires effective and efficient communication and teamwork among all members [33,34]. Good care begins with a pre-arrival briefing and the assignment of general roles and specific tasks, and continues throughout the resuscitation as the team uses closed loop communication and maintains a common vision of the plan of care. Notably, it is important to include the alert patient (or health care proxy) in this communication, keeping them informed of the plan of care and any changes [35].

Breakdowns in the care plan and medical mismanagement typically occur due to one or more of four potential problems [34]:

Communication breakdowns (eg, changes in the patient's physiologic state or critical test results are not effectively communicated, overall management plan or priority of tasks is not conveyed clearly by the team leader)

Failures in situational awareness (eg, failure to recognize shock, failure to anticipate blood transfusion needs, failure to modify standard management for higher risk patients)

Staffing or workload distribution problems (eg, insufficiently trained staff conducting a procedure, inadequate staff for patient volume)

Unresolved conflicts (eg, unresolved hostility about other team members perceived to be performing inadequately, disagreement about overall management plan, disagreement among senior clinicians vying for team leadership)


Overview — A clear, simple, and organized approach is needed when managing a severely injured patient. The primary survey promulgated in Advanced Trauma Life Support™ (ATLS™) provides such an approach [25]. The primary survey is organized according to the injuries that pose the most immediate threats to life and is performed in the order described below. In settings with limited resources, the primary survey simplifies priorities and any problems identified should be managed immediately before moving on to the next step of the survey. However, at major trauma centers, many capable clinicians may be present, allowing the team to address multiple problems simultaneously.

The primary survey consists of the following steps:

Airway assessment and protection (maintain cervical spine stabilization when appropriate)

Breathing and ventilation assessment (maintain adequate oxygenation)

Circulation assessment (control hemorrhage and maintain adequate end-organ perfusion)

Disability assessment (perform basic neurologic evaluation)

Exposure, with environmental control (undress patient and search everywhere for possible injury, while preventing hypothermia)

Keep the following points in mind while performing the primary survey:

Airway obstruction is a major cause of death immediately following trauma [27,33]. The airway may be obstructed by the tongue, a foreign body, aspirated material, tissue edema, or expanding hematoma.

Definitive guidelines for tracheal intubation in trauma do not exist. When in doubt, it is generally best to intubate early, particularly in patients with hemodynamic instability, or those with significant injuries to the face or neck, which may lead to swelling and distortion of the airway.

Once an airway has been established, it is important to secure it well and to ensure it is not dislodged any time the patient is moved. Unintended extubation is the most common preventable cause of morbidity in trauma patients [22].

Unconscious patients with small pneumothoraces that are not visible or missed on the initial chest radiograph may develop tension physiology after tracheal intubation from positive pressure ventilation. It is important to reauscultate the lungs of trauma patients who develop hemodynamic instability after being intubated and to be attentive to ventilator pressure alarms.

Hemorrhage is the most common preventable cause of mortality in trauma [21]. Be alert for subtle signs of hemorrhagic shock, particularly in the elderly, who may be on cardiovascular medications that blunt such signs, and young, healthy adults who may not present with obvious manifestations. Hypotension generally does not manifest until at least 30 percent of the patient's blood volume has been lost [36]. Such patients are at high risk of death. Elderly patients may be hypotensive relative to their baseline blood pressure but still have blood pressure measurements in the "normal" range. A single episode of hypotension substantially increases the likelihood that a serious injury has occurred [37,38]. (See "Initial evaluation of shock in the adult trauma patient and management of NON-hemorrhagic shock", section on 'Recognition of shock' and "Geriatric trauma: Initial evaluation and management".)

Brain injuries are common in patients who have sustained severe blunt trauma and even a single episode of hypotension increases their risk of death [36,39].

Airway — Severely injured patients can develop airway obstruction or inadequate ventilation leading to hypoxia and death within minutes. Observational studies suggest that airway obstruction is a major cause of preventable death among trauma patients [40,41]. Therefore, airway evaluation and management remain the critical first steps in the treatment of any severely injured patient [25].

Several studies suggest that checklists improve the efficiency and reduce the complications associated with airway management of trauma patients [42-45]. In a prospective study of 141 intubated trauma patients, implementation of pre-arrival and pre-induction preparation checklists reduced intubation-related complication rates by 7.7 percent (95% CI 0.5-14.8) [42]. A sample checklist is provided in the accompanying table (table 2).

Maintaining the patient’s stretcher at a slight angle with the head slightly elevated (reverse Trendelenburg position) or elevating just the head to about 30 degrees if cervical spine precautions are not required can help to decrease the risk of aspiration and improve lung capacity by reducing abdominal pressure on the chest.  

Assessment — In a conscious patient, initial airway assessment can be performed as follows [46]:

Begin by asking the patient a simple question (eg, "What is your name?"). A clear accurate response verifies the patient's ability to mentate, phonate, and to protect their airway, at least temporarily.

Observe the face, neck, chest, and abdomen for signs of respiratory difficulty, including tachypnea, accessory or asymmetric muscle use, abnormal patterns of respiration, and stridor.

Inspect the oropharyngeal cavity for disruption; injuries to the teeth or tongue; blood, vomitus, or pooling secretions. Note if there are obstacles to the placement of a laryngoscope and endotracheal tube.

Inspect and palpate the anterior neck for lacerations, hemorrhage, crepitus, swelling, or other signs of injury. Palpation of the neck also enables identification of the landmarks for cricothyrotomy.

In the unconscious patient, the airway must be protected immediately once any obstructions (eg, foreign body, vomitus, displaced tongue) are removed. Management of the airway generally and in a patient with direct airway trauma is discussed separately. (See "Emergency airway management in the adult with direct airway trauma" and "Penetrating neck injuries: Initial evaluation and management" and "Advanced emergency airway management in adults" and "Rapid sequence intubation for adults outside the operating room".)

Airway management in a trauma patient unable to protect his or her airway is completed in an expedient yet controlled fashion. When possible, perform a brief preintubation assessment to gauge the potential difficulty of intubation and determine basic baseline neurologic function (eg, pupillary light reflex, movement of extremities). Methods and mnemonics to assess airway difficulty are reviewed separately, but the application of the LEMON mnemonic to trauma patients is described here. (See "Approach to the difficult airway in adults outside the operating room".)

L: LOOK: Facial and neck injuries can distort external and internal structures making it difficult to visualize the glottis or insert an endotracheal tube.

E: EVALUATE 3-3-2: This refers to the intraoral, mandibular, and hyoid-to-thyroid notch distances (picture 1). The cervical collar must be opened to make these assessments. The distances referred to can be narrowed by fracture, hematoma, or other anatomic distortions (eg, soft tissue swelling).

M: MALLAMPATI: A standard calculation of the Mallampati score cannot be performed in many trauma patients; injured patients requiring emergent intubation often cannot open their mouths spontaneously (figure 1). Nevertheless, an effort should be made to determine how much of the retropharynx can be seen and whether injuries of the oropharynx or pooled blood, vomitus, or secretions are present.

O: OBSTRUCTION/OBESITY: Either factor can interfere with visualization and management of the traumatized airway. Any number of injuries can obstruct the airway including internal or external hematomas or soft tissue edema from smoke inhalation. Obesity complicates performance of cricothyrotomy.

N: NECK MOBILITY: In-line stabilization is necessary in most trauma patients. Once the cervical collar is removed by a second skilled provider, that provider should stabilize the spine while orotracheal intubation is performed. It is important to note that the risk of neurologic injury from hypoxemia is much greater than the risk of spinal injury due to neck extension during intubation. Judicious relaxation of immobilization may be necessary in some cases [46].

Difficult airway devices — Devices for difficult airway management are discussed separately. (See "Devices for difficult emergency airway management outside the operating room in adults".)

A number of airway tools and rescue airways can be helpful when managing a trauma patient. Devices that should be available at the bedside include:

Suction (ie, multiple pumps and tips)

Bag-valve mask attached to high flow oxygen

Oral and nasal airways

Rescue airways (eg, Combitube, Laryngeal mask airway)

Endotracheal tube introducer (ie, gum elastic bougie)

Video laryngoscope, if available

Cricothyrotomy kit

Endotracheal tubes in a range of sizes

Laryngoscopes, including a range of different sized blades and handles

Preferred adjunct intubating devices (eg, lightwand)

Direct laryngoscopy relies on direct visualization of the glottis, which is often difficult in the severely injured patient whose airway may be obstructed and whose neck cannot be manipulated. In contrast, video laryngoscopes provide an excellent view of the glottis with minimal movement of the cervical spine and appear to be well suited for airway management in the trauma patient [47-49]. Larger studies in trauma populations are needed to confirm these initial impressions.

The endotracheal tube introducer (or gum elastic bougie) is another invaluable tool for airway management in the trauma patient, particularly when the glottic view is limited. Its use is discussed separately. (See "Devices for difficult emergency airway management outside the operating room in adults", section on 'Endotracheal tube introducers (gum elastic bougie)'.)

Intubation — Tracheal intubation of the injured patient is often complicated by the need to maintain cervical immobilization, the presence of obstructions such as blood, vomitus, and debris, and possibly by direct trauma to the airway [50]. Nevertheless, many trauma patients require intubation for immediate airway protection or because of the projected disease course. Intubation improves oxygenation, thereby helping to meet increased physiologic demands, and allows for testing and procedures to be performed more easily and with less patient discomfort. (See "The decision to intubate".)

Ideally, airway managers should have a predetermined back-up plan with all necessary tools at the bedside, including rescue airways and a cricothyrotomy kit, before proceeding with intubation. In crash scenarios, this may not be possible. A sample checklist to assist with airway management of the adult trauma patient is provided in the accompanying table (table 2).

Clinicians should consider the expected course of disease and need for interventions when deciding to secure an airway. Patients often warrant early intubation to ensure airway protection or to allow for deeper sedation and pain control. Examples of this include: a patient who is hemodynamically stable for the moment but at risk of deterioration and who requires a complex diagnostic study that must be performed in a remote radiology suite; and a patient with significant injury in imminent need of an orthopedic or other painful procedure. Critically ill trauma patients at risk for hypotension following sedation and paralysis for intubation should be treated aggressively prior to intubation. Post-intubation hypotension should be anticipated and mitigated as much as possible. In a retrospective review of 444 patients, in-hospital mortality was nearly doubled for those who had a single episode of post-intubation hypotension compared with those who did not (29.8 versus 15.9 percent) [51].

The performance of rapid sequence intubation and direct laryngoscopy are discussed separately. (See "Rapid sequence intubation for adults outside the operating room" and "Direct laryngoscopy and endotracheal intubation in adults".)

Cricothyrotomy — Clinicians who manage trauma must be prepared to perform a cricothyrotomy when orotracheal intubation cannot be accomplished. The performance of cricothyrotomy and the approach to the failed airway are discussed separately. (See "Approach to the failed airway in adults outside the operating room" and "Emergency cricothyrotomy (cricothyroidotomy)".)

In trauma patients with a potentially difficult airway, a double set-up, in which simultaneous preparation is made to perform orotracheal intubation and cricothyrotomy, may be the best approach. This enables the clinician to transition immediately to a cricothyrotomy if attempts at oral intubation are unsuccessful.

Trauma patients may have sustained injuries to the neck that make cricothyrotomy difficult to perform, and therefore, it is important to optimize any attempt at orotracheal intubation.

Cervical spine immobilization — Assume that an injury to the cervical spine has occurred in all blunt trauma patients until proven otherwise. Conversely, patients with isolated penetrating trauma, no secondary blunt injury, and an intact neurologic examination typically do not have an unstable spinal column injury [46]. Spinal immobilization may be harmful to these patients in some circumstances and is unnecessary when managing their airway [52]. (See "Evaluation and acute management of cervical spinal column injuries in adults".)

The anterior portion of the cervical collar should be temporarily removed and manual in-line stabilization maintained for all patients with blunt traumatic injuries receiving airway interventions, including bag-mask ventilation [53,54]. Preintubation airway interventions are associated with as much spinal column subluxation as intubation [53,54].

Tracheal intubation should not be attempted with the anterior portion of the cervical collar in place. Intubations performed with the complete cervical collar in place are associated with greater spinal subluxation than those performed with the anterior portion removed and manual in-line stabilization maintained [55].

The safety of manual in-line stabilization for patients with blunt traumatic injuries needing intubation is well established. Few case reports describe spinal injury during intubation, and in all cases, the spine was not manually stabilized [56-58].

Breathing and ventilation — Once airway patency is ensured, assess the adequacy of oxygenation and ventilation [25]. Chest trauma accounts for 20 to 25 percent of trauma-related deaths, in large part due to its harmful effects on oxygenation and ventilation [24]. The management of blunt chest trauma is discussed separately. (See "Initial evaluation and management of blunt thoracic trauma in adults".)

Inspect the chest wall looking for signs of injury, including asymmetric or paradoxical movement (eg, flail chest), auscultate breath sounds at the apices and axillae, and palpate for crepitus and deformity. In unstable patients, obtain a portable chest radiograph. Tension pneumothorax, massive hemothorax, and cardiac tamponade are immediate threats to life that should be identified at this stage of the primary survey. Ultrasound can provide important information about all these diagnoses during this portion of the assessment. (See 'Ultrasound (FAST exam)' below and "Emergency ultrasound in adults with abdominal and thoracic trauma".)

Presumptively treat patients exhibiting signs of tension pneumothorax, including hypotension, dyspnea, and ipsilateral decreased breath sounds, with needle decompression before obtaining imaging. Delays to obtain a portable chest radiograph can cause significant morbidity. If confirmation is needed prior to treatment, ultrasound can be performed rapidly at the bedside, and it is more sensitive than plain radiograph for detecting pneumothorax [59]. Needle decompression is performed with a large bore (14 gauge or larger) angiocatheter, either in the second intercostal space in the midclavicular line or in the fifth intercostal space in the midaxillary line. If equipment is immediately available, it is appropriate to proceed directly to chest tube insertion without intervening needle decompression.

Of note, a standard 14-gauge angiocatheter cannot penetrate the chest wall and reach the pleural space in 10 to 33 percent of trauma patients [60]. A 10-gauge, 7.5 cm (3 inch) armored angiocatheter is able to penetrate the pleural space in most instances. Needle decompression is followed immediately by tube thoracostomy. (See "Initial evaluation and management of blunt thoracic trauma in adults", section on 'Initial management' and "Placement and management of thoracostomy tubes".)

Tube thoracostomy in an unstable trauma patient is placed in anticipation of both hemothorax and pneumothorax using a chest tube of at least 32 French in diameter. A generous skin incision should be made in the fifth intercostal space in the midaxillary line allowing for placement of the tube in the inferior portion of the interspace and digital guidance towards the posterior-apical portion of the hemithorax.


Recognition and management of hemorrhage — Once the airway and breathing are stabilized, perform an initial evaluation of the patient's circulatory status by palpating central pulses. If a carotid or femoral pulse is verified and no obvious exsanguinating external injury is noted, circulation may momentarily be assumed to be intact; completion of the primary survey should not be delayed by the determination of an exact blood pressure.

While circulation is assessed, two large-bore (16 gauge or larger) intravenous (IV) catheters are placed, most often in the antecubital fossa of each arm, and blood is drawn for testing, particularly for blood typing and crossmatch. Intraosseous cannulation or central venous catheter placement (ideally under ultrasound guidance) can be performed if there is difficulty establishing peripheral IV access. (See "Intraosseous infusion".)

Life-threatening hemorrhage must be controlled. A combination of manual pressure, proximal compression with either a tourniquet or a manual blood pressure cuff, and elevation is typically sufficient to control external arterial hemorrhage. When these are unsuccessful, hemostatic agents may be used, if available. Venous bleeding is controlled with direct pressure. Bleeding from severe pelvic injuries may require the application of a pelvic binder. (See "Pelvic trauma: Initial evaluation and management", section on 'Management' and "Initial management of moderate to severe hemorrhage in the adult trauma patient", section on 'Hemostatic agents'.)

Emergency thoracotomy may be needed for trauma patients without femoral or carotid pulses. The procedure is most effective for victims of stab wounds to the chest who have pulses or other witnessed signs of life (eg, voluntary movement) initially. It is rarely beneficial in patients with blunt trauma or when performed in facilities without ready access to appropriate surgical care. Of note, trauma patients who require cardiopulmonary resuscitation (CPR) within one hour of hospital arrival have a low rate of survival to hospital discharge (only 13 percent in one study [61]), so maintaining perfusion and the need for CPR is exceptionally important. Emergency thoracotomy is discussed in greater detail separately. (See "Initial evaluation and management of penetrating thoracic trauma in adults", section on 'Emergency department thoracotomy (EDT)' and "Initial evaluation and management of blunt thoracic trauma in adults", section on 'Emergency thoracotomy' and "Resuscitative thoracotomy: Technique".)

In patients in extremis with impending arrest, placement of a resuscitative balloon for occlusion of the aorta (REBOA) by those trained in this technique may be life-saving [62,63]. Use of this device is most effective to temporize patients with intra-abdominal or retroperitoneal sources of hemorrhage until more definitive therapy with surgery or angioembolization is possible, and so rapid transport to the operating room and/or angiographic suite is essential. REBOA is not appropriate for use in those with suspected thoracic sources of exsanguination or in patients in cardiac arrest, in whom EDT should be performed instead. (See "Endovascular methods for aortic control in trauma", section on 'REBOA technique'.)

Most trauma patients with hypotension or signs of shock (eg, pale, cool, moist skin) are bleeding, and patients with severe hemorrhage have significantly higher mortality (table 3) [64]. Initial fluid resuscitation for these patients may consist of a bolus of intravenous crystalloid (eg, 20 mL/kg isotonic saline). However, patients with obvious severe or ongoing blood loss should be transfused immediately with type O blood (women of childbearing age should be transfused with O negative blood). While mildly unstable patients may be treated with isotonic crystalloid in lieu of blood, unnecessary infusion of crystalloid should be avoided [65]. Fluid resuscitation, including the appropriate use of delayed fluid resuscitation and transfusion of the trauma patient in shock are discussed separately. (See "Initial evaluation of shock in the adult trauma patient and management of NON-hemorrhagic shock".)

Patients with persistent hemodynamic instability despite an initial fluid bolus generally require blood transfusion and definitive control of the bleeding source. Significant hemorrhage occurs in any of five sites: external, intrathoracic, intraperitoneal, retroperitoneal, and pelvic or long bone fractures. If transfusion is required, a 1:1:1 ratio of plasma, platelets, and red cells should be targeted [66]. Patients requiring transfusion may benefit from treatment with tranexamic acid if it is given within three hours of injury. Transfusion of the trauma patient and the use of antifibrinolytic agents such as tranexamic acid are discussed in detail separately. (See "Initial evaluation of shock in the adult trauma patient and management of NON-hemorrhagic shock" and "Initial management of moderate to severe hemorrhage in the adult trauma patient".)

It is important to obtain manual blood pressure measurements in trauma patients with systolic blood pressures below 90 mmHg, as automated blood pressure cuffs often overestimate values significantly in these patients [67]. Furthermore, data suggest that the traditional threshold of a systolic blood pressure below 90 mmHg to define shock is inaccurate [68-71]. The appropriate systolic or mean arterial blood pressure threshold for defining shock varies by age. A significant proportion of trauma patients with hemorrhagic shock have a systolic blood pressure above 90 mmHg; using a cut-off of 110 mmHg is likely to be more appropriate in the elderly. (See "Geriatric trauma: Initial evaluation and management".)

Reversal of anticoagulation — Some trauma patients, particularly elders with comorbidities, may be taking anticoagulants. Provided below are several tables outlining methods for reversing particular anticoagulants in cases of life-threatening bleeding, as well as links to more detailed discussions of how to manage bleeding associated with these medications:

Warfarin (see "Management of warfarin-associated bleeding or supratherapeutic INR", section on 'Serious/life-threatening bleeding'). Initial emergency treatment to reverse anticoagulation due to warfarin in patients with severe hemorrhage is outlined in the following table (table 4).

Direct thrombin inhibitors (eg, dabigatran) and factor Xa inhibitors (eg, rivaroxaban, apixaban, edoxaban) (see "Management of bleeding in patients receiving direct oral anticoagulants"). Initial emergency treatment to reverse anticoagulation due to direct oral anticoagulants in patients with severe hemorrhage is outlined in the following table (table 5).

Heparin (see "Heparin and LMW heparin: Dosing and adverse effects", section on 'Bleeding').

Low molecular weight heparin (see "Heparin and LMW heparin: Dosing and adverse effects", section on 'Bleeding').

Nonhemorrhagic causes of shock — In adult trauma patients, nonhemorrhagic causes of shock include tension pneumothorax and cardiac tamponade. These injuries are best detected by physical examination or ultrasound assessment (ie, FAST). Particularly in older patients, the clinician may need to consider medical causes of hypotension that preceded and possibly caused the trauma, such as myocardial infarction, arrhythmia, malfunctioning pacemaker or left ventricular assist device (LVAD), or gastrointestinal bleeding. (See 'Ultrasound (FAST exam)' below and "Emergency ultrasound in adults with abdominal and thoracic trauma" and "Geriatric trauma: Initial evaluation and management" and "Initial evaluation of shock in the adult trauma patient and management of NON-hemorrhagic shock", section on 'Differential diagnosis'.)

Disability and neurologic evaluation — Once problems related to the airway, breathing, and circulation are addressed, perform a focused neurologic examination. This should include a description of the patient's level of consciousness using the Glasgow Coma Scale (GCS) score, and assessments of pupillary size and reactivity, gross motor function, and sensation (table 6). Also note any lateralizing signs and the level of sensation if a spinal cord injury is present. Acute neurologic injury, including imaging recommendations and medical and surgical management, is discussed in detail separately. (See "Management of acute severe traumatic brain injury" and "Acute traumatic spinal cord injury".)

The GCS score is widely used and can be employed to follow the patient's neurologic status. Unfortunately, a number of studies suggest that the initial GCS score is not predictive of outcome in patients with severe brain injury, and intubation, sedatives, and alcohol or other drug intoxication may interfere with its application [72-74].

Maintain spinal immobilization for all patients with the potential for spinal cord injury. The presence of a motor deficit or a spinal cord sensory level indicates the need for imaging of the brain, spinal cord, and their vascular supply.

Exposure and environmental control — Be certain that the trauma patient is completely undressed and that his or her entire body is examined for signs of injury during the primary survey. Missed injuries pose a grave threat [75]. Regions often neglected include the scalp, axillary folds, perineum, and in obese patients, abdominal folds. Penetrating wounds may be present anywhere. While maintaining cervical spine precautions, examine the patient's back; do not neglect examination of the gluteal fold and posterior scalp.

Hypothermia should be prevented if possible and treated immediately once identified. Hypothermia contributes to both coagulopathy [76] and the development of multiple organ dysfunction syndrome [77]. During winter months and whenever a hypothermic trauma patient is being treated, the resuscitation room should be heated; the United States Military Joint Theater Trauma System Clinical Practice Guideline on hypothermia prevention recommends emergency department (ED) and operating room (OR) temperatures of at least 29.4°C (85°F) during the treatment of these patients [78]. Rapidly remove wet clothing, make liberal use of warm blankets and active external warming devices, and warm IV fluids and blood. Treatments for hypothermia are discussed separately. (See "Accidental hypothermia in adults".)

Diagnostic studies

Portable radiographs — Plain radiographs play an important role in the primary evaluation of the unstable trauma patient. Screening radiographs should be obtained, either in the emergency department (ED) or the operating room (OR), even in hemodynamically compromised patients who are sent directly to the OR during or after their primary survey. Prompt imaging of the lateral cervical spine, chest, and pelvis can detect life threatening injuries that might otherwise be missed. However, the sensitivity of the lateral cervical spine radiograph is only 70 to 80 percent [79-81], and some sacral and iliac fractures can be missed on plain pelvic radiographs.

Clinical decision rules (eg, NEXUS) can be used to determine the need for cervical spine imaging in hemodynamically stable trauma patients. Assessment of the spinal column injuries in trauma, including the selection of imaging studies, is discussed separately. (See "Evaluation and acute management of cervical spinal column injuries in adults".)

Plain radiography of the chest and pelvis is often obtained for trauma patients not thought to require CT imaging. The decision to obtain these images should be made based upon the injury mechanism and clinical findings. The evaluation of patients with penetrating trauma often includes images of the region of penetration; even in stable patients, these radiographs can detect retained foreign bodies or fragments. On the other hand, patients with blunt trauma should undergo imaging with plain radiographs only if clinical findings suggest the presence of injury [82,83]. Plain radiographs can be omitted altogether if there is no clinical suspicion of injury and the studies are unlikely to alter emergent management. (See "Pelvic trauma: Initial evaluation and management", section on 'Plain radiograph'.)

A plain radiograph of the chest should be obtained in patients with penetrating injuries of the chest, back, or abdomen regardless of the need for CT. Plain films may reveal subdiaphragmatic free air, a foreign body, or a pneumothorax or hemothorax.

If the clinician determines that CT imaging is needed based upon the mechanism or clinical suspicion, there is no role for either a plain radiograph of the chest or pelvis in hemodynamically stable patients with blunt trauma [82,84-87].

Ultrasound (FAST exam) — Focused Assessment with Sonography for Trauma (FAST) is an essential part of the primary circulation survey for unstable patients, in whom it often determines management [88-93]. FAST is used primarily to detect pericardial and intraperitoneal blood, and it is more accurate than any physical examination finding for detecting signs of intra-abdominal injury. In hemodynamically stable patients, FAST can be delayed until the secondary survey and is ideally performed by a second operator while the remainder of the secondary survey is completed. The performance of the FAST examination and evidence supporting its use are discussed separately. (See "Emergency ultrasound in adults with abdominal and thoracic trauma".)

The accuracy and role of FAST may be more limited in patients with significant pelvic fractures because it is less sensitive for detecting pelvic bleeding and cannot differentiate between blood and urine. Retroperitoneal bleeding is also not reliably visualized with ultrasound. The management of such patients is discussed separately. (See "Pelvic trauma: Initial evaluation and management", section on 'Initial management'.)

FAST is less sensitive for injury in penetrating trauma than blunt trauma, and the results of ultrasound examinations in penetrating trauma patients, particularly negative results, must be interpreted with caution. (See "Emergency ultrasound in adults with abdominal and thoracic trauma", section on 'Clinical studies'.)

The Extended FAST (E-FAST) includes examinations of the thoracic cavity looking for pneumothoraces. Preliminary studies suggest the sensitivity of E-FAST is better than plain radiograph for this injury [94].

Emergency computed tomography (CT) — Trauma patients found to be hemodynamically unstable during the primary survey are aggressively resuscitated while clinicians attempt to determine the most likely causes of their instability. If the source of hemorrhage in an unstable trauma patient cannot be determined using diagnostic imaging studies immediately available at the bedside, or if additional information is needed to direct operative care, in most cases the treating emergency physician and surgeon must decide whether to perform emergency CT imaging first or to take the patient directly to the operating room. This decision is based upon the patient's response to initial resuscitation measures, their probable injuries and anticipated operative intervention, and the proximity of the CT scanner to the resuscitation bay. The issue of total body CT is discussed separately. (See 'Computed tomography, including total body CT' below.)

Imaging must not delay transfer in situations when patients require higher levels of care than can be provided at the initial facility. If transfer will be needed, the process should be initiated as early as possible (in some cases, immediately upon patient arrival and assessment). If CT imaging is needed and can safely and reasonably be done without delaying transfer, it may be obtained. (See 'Patient transfer' below.)

In rare instances, patients may have known and potentially life-threatening allergies to IV contrast [95]. In such cases, assessment options include: non-contrast CT, ultrasound, exploratory surgery, and (when patient stability and resources allow) MRI or radionuclide red cell scan [96].

Diagnostic peritoneal tap or lavage — Diagnostic peritoneal tap (DPT) or lavage (DPL) has a role similar to FAST in the unstable patient in whom a source of bleeding has not been found [97]. It can be performed to detect intraperitoneal blood when FAST is unavailable or indeterminate in hemodynamically unstable patients, to determine the type of intraperitoneal fluid when it is important to do so (eg, blood versus urine in the setting of a pelvic fracture), or at physician discretion. (See "Initial evaluation and management of blunt abdominal trauma in adults", section on 'Diagnostic peritoneal lavage (DPL)'.)

Electrocardiogram — An electrocardiogram (ECG) should be obtained for all patients injured by mechanisms with the potential to cause cardiac injury. Signs of blunt cardiac injury can include arrhythmias, significant conduction delays, or ST segment changes. Findings consistent with pericardial tamponade include tachycardia, low voltage, and electrical alternans. If ECG findings consistent with cardiac injury are present, formal echocardiography (in addition to the FAST examination) should be performed. In addition, cardiac monitoring should continue throughout the trauma evaluation and resuscitation, including during diagnostic testing, as changes in heart rate and blood pressure may herald rapid clinical deterioration. (See "Cardiac injury from blunt trauma" and "Cardiac tamponade".)

Laboratory tests — The practice of obtaining routine “screening" laboratory tests on trauma patients is neither useful nor cost-effective [98,99]. Testing should be performed based upon clinical suspicion and should be limited to those tests that may alter management. As examples, a pregnancy test (eg, urine hCG) should always be performed on women of child-bearing age, and a blood type and screen or crossmatch should be obtained for patients with significant trauma who may reasonably be expected to require transfusion.

Clinical circumstances determine the need for further testing. As examples, patients taking warfarin likely need coagulation studies (eg, prothrombin time) and patients found on the ground for an undetermined time need studies (eg, creatine kinase) to determine if rhabdomyolysis is present. (See "Clinical features and diagnosis of heme pigment-induced acute kidney injury".)

At initial presentation, the need for transfusion of blood products in the severely injured trauma patient is determined on clinical grounds, and may involve massive transfusion protocols. Thereafter, routine coagulation studies do not predict coagulopathy accurately in the acute trauma patient; where available, thromboelastography provides a faster and more accurate means for detecting imbalances in the hemostatic system and assessing ongoing needs for treatment. (See "Coagulopathy associated with trauma".)

Commonly obtained but rarely helpful tests include the metabolic panel (a fingerstick blood sugar will often suffice, provided the patient is not exhibiting signs of electrolyte abnormality or acidosis), alcohol level in a patient who is clearly intoxicated, toxicologic screen when it is not relevant to clinical care, and cardiac biomarkers, unless cardiac contusion or ischemia is suspected [100]. (See "Cardiac injury from blunt trauma", section on 'Diagnostic tests'.)

Elevation of both the serum lactate concentration and base deficit correlates with increased mortality in trauma patients [101-104]. However, the base deficit is essentially a surrogate for lactate and an elevated base deficit in the absence of an elevated lactate is not predictive of increased mortality [105]. Furthermore, while elevated levels should heighten suspicion for severe injury, a normal lactate and base deficit do not ensure the absence of significant injury, especially in geriatric trauma patients. In addition, laboratory values lag behind clinical improvement after aggressive resuscitation. Thus, the patient may no longer be in shock despite an elevated lactate suggesting otherwise [106,107]. (See "Geriatric trauma: Initial evaluation and management".)

The white blood cell (WBC) count is nonspecific and of little value during the initial evaluation of the trauma patient [99]. The positive and negative predictive value of, respectively, an elevated or normal WBC is poor. Epinephrine release from trauma can cause demargination and may elevate the WBC to 12,000 to 20,000/mm3 with a moderate left shift. Solid or hollow viscus injury can cause comparable elevations [108].

PATIENT TRANSFER — Clinicians at hospitals with limited resources to manage trauma should consult the nearest trauma center as soon as it becomes apparent that a patient has sustained injuries beyond the management capacity of their hospital. Many patients needing to be transferred for trauma evaluation are not sent. In a review of National Trauma Data Bank, only 20 percent of patients initially taken to nontertiary centers and meeting trauma guideline criteria for transfer were subsequently transferred [109]. The risk adjusted odds for mortality was higher for nontransferred patients compared with those who were treated at level I or II trauma centers.

Patients should be stabilized as well as possible without delaying transfer; delays are associated with increased mortality [110,111]. Criteria for transfer are based upon the patient's demographics, mechanism of injury, and clinical findings. It cannot be overemphasized that a complete workup is not a requirement for transfer; postponing transfer to obtain laboratory results or imaging studies only delays definitive treatment. Often such studies must be repeated at the receiving facility.

Computed tomography (CT) imaging should only be obtained in patients who might otherwise be appropriately treated at the initial facility. If a negative CT would allow the patient to be discharged, it should be performed, but if that patient requires transfer regardless of the results, then transfer should not be delayed. Likewise, procedures and other interventions should only be performed to treat emergency conditions or prevent possible patient deterioration during transport. Endotracheal intubation, tube thoracostomy, and pelvis fracture stabilization are common examples of necessary interventions; laceration repair, unless it is performed to prevent exsanguination, is not. For hemodynamically unstable patients, blood – if available – should be transfused. Transfusion can begin at the initial facility or be performed during transport by sending units of blood with the emergency transport team.

The decision of when to transfer an unstable patient should ideally be made by the transferring and receiving physicians in collaboration. Clear communication is critical: the transmission of vital information allows receiving clinicians to mobilize needed resources while the inadvertent omission of such information can delay definitive care. Information should be conveyed in both verbal and written (via the patient record) form and should include the patient's identifying information, relevant medical history, prehospital course, and ED evaluation and treatment (including procedures performed and imaging obtained) [25]. The use of a transfer checklist can help to ensure that important information is not omitted.

SECONDARY EVALUATION — Definitive management of a hemodynamically unstable trauma patient must not be delayed to perform a more detailed secondary evaluation. Such patients are taken directly to the operating room (OR) or angiography suite, or transferred to a major trauma center.

A careful, head-to-toe secondary assessment (ie, secondary survey) is performed in all trauma patients determined to be stable upon completion of the primary survey. The secondary survey includes a detailed history, a thorough but efficient physical examination, and targeted diagnostic studies, and plays a crucial role in avoiding missed injuries. Commonly missed injuries include [112-114]:

Blunt abdominal trauma: Hollow viscus injury, pancreatoduodenal injuries, diaphragmatic rupture

Penetrating abdominal trauma: Rectal and ureteral injuries

Thoracic trauma: Aortic injuries, pericardial tamponade, esophageal perforation

Extremity trauma: Fractures (especially in distal extremities), vascular disruption, compartment syndrome

Delayed reevaluation of the trauma patient (ie, tertiary survey) is also useful for preventing missed injuries and for detecting injuries that present late [112]. It is most helpful if the patient is reevaluated when fully alert. Any member of the trauma team with advanced assessment skills can perform the tertiary survey; however, it is best if the same clinician performs all serial examinations for a given patient in order to detect subtle changes.

History — The mechanism of injury can increase suspicion for certain injuries. Prehospital personnel often know important information and should be queried regarding the mechanism and history of the injury. If this cannot be done immediately upon arrival because of the patient's status, ask the prehospital providers to remain in the emergency department (ED) until this can be accomplished. Often the history is conveyed while medics and hospital clinicians transfer the patient and important information may be forgotten or missed.

While listening to the history, keep in mind that the scenes of accidents can be chaotic and not all information will be reliable. As an example, a patient described as "found down" may have been assaulted or struck by a car.

Mechanism-related information to be obtained from prehospital personnel includes [115]:

Blunt trauma

Seat belt use

Steering wheel deformation

Airbag deployment

Direction of impact

Damage to the automobile (especially intrusion into the passenger compartment)

Distance ejected from the vehicle

Height of fall

Body part landed upon

Penetrating trauma

Type of firearm

Distance from firearm

Number of gunshots heard

Type of blade

Length of blade

Inquire also about the patient's medications, allergies, and medical and surgical history. If this information is unknown, it can be helpful to assign someone the task of contacting family members to obtain it. The use of anticoagulant and antiplatelet medications is steadily rising and increases the risk of internal bleeding in trauma patients, and therefore these agents should specifically be discussed [116-118].

As an example of the risks associated with anticoagulants, a retrospective study of 11,374 adult trauma patients reported that the use of antiplatelet drugs was associated with an increased risk of death (propensity adjusted outcome 9.4 versus 8 percent mortality) and major morbidity among the 1327 (11.7 percent) patients taking them at the time of their injury [116]. Patients taking multiple antiplatelet medications were at greater risk than those taking a single drug.

While such questions do not typically affect the immediate treatment of traumatic injuries, it is important to ask trauma patients about possible domestic violence. The reported prevalence of domestic violence continues to increase among both children and adults, and can lead to a pattern of repeated traumatic injury [119]. (See "Intimate partner violence: Diagnosis and screening" and "Intimate partner violence: Childhood exposure" and "Elder mistreatment: Abuse, neglect, and financial exploitation" and "Peer violence and violence prevention".)

A history of mental illness, including thoughts or attempts at suicide, may be significant, particularly in the setting of single car accidents or falls from a height, which may be initially unrecognized suicide attempts. Knowledge of alcohol or drug abuse may help to detect or prevent withdrawal during hospital admission.

Physical examination — The goal of the secondary survey is to identify injuries. This includes the performance of a thorough but efficient physical examination. Use standard precautions against blood or fluid-borne infection.

Head and face — Inspect and palpate the entire bony structure of the head and face for tenderness, deformity (eg, step off), and bleeding. Scalp lacerations are easily missed visually but often found by palpation. Be attentive for foreign bodies, such as glass in the scalp after a car accident.

Note any signs suggesting basilar skull fracture (eg, hemotympanum). Retroauricular (Battle's sign) and periorbital ecchymosis (raccoon's eyes) are also indicative of basilar skull fracture but generally do not appear until at least 24 hours after an injury. Look for nasal septal hematomas. (See "Skull fractures in adults" and "Initial evaluation and management of facial trauma in adults".)

Perform an ocular examination including an evaluation of pupillary size, shape, reactivity, and extraocular movement. Look for signs of globe rupture and intraocular hemorrhage. (See "Open globe injuries: Emergency evaluation and initial management" and "Orbital fractures" and "Retinal detachment" and "Traumatic hyphema: Clinical features and diagnosis".)

Patients with mild traumatic brain injury may not have external signs of trauma. Validated decision tools, including the New Orleans Criteria [120] and the Canadian CT Head Rule [121], can be used to determine the need for neuroimaging [122] with computed tomography (CT). (See "Acute mild traumatic brain injury (concussion) in adults".)

Neck — Assume that all patients with blunt trauma have sustained an injury to the cervical spine. This assumption can be disproved by appropriate application of clinical decision rules, such as NEXUS or the Canadian C-Spine Rule, or by radiologic evaluation using plain radiographs or CT. Assessment of the cervical spine following trauma is discussed separately. (See "Evaluation and acute management of cervical spinal column injuries in adults".)

Inspect and palpate the entire neck for signs of injury. The management of penetrating neck trauma is discussed separately. (See "Penetrating neck injuries: Initial evaluation and management".)

Chest — Inspect and palpate the entire chest wall. Pay particular attention to the sternum and clavicles. Injuries at these sites are often missed, and fractures of these bones suggest the presence of further injury, including of intrathoracic structures. Careful auscultation can detect a previously missed small hemothorax, pneumothorax, or pericardial effusion not yet causing tamponade. The NEXUS-Chest criteria may be used to determine whether chest imaging is necessary in an adult following blunt trauma [123]. (See "Initial evaluation and management of blunt thoracic trauma in adults".)

Abdomen — Perform and document a careful abdominal examination. Inspect the abdomen and flanks for lacerations, contusions (eg, seat belt sign), and ecchymosis; palpate for tenderness and rigidity. The presence of a seat belt sign, rebound tenderness, abdominal distension, or guarding all suggest intra-abdominal injury. Note that the absence of abdominal tenderness does not rule out such injury.

Keep in mind that the abdominal examination is often unreliable, particularly in the elderly, patients with distracting injuries or altered mental status, and patients late in pregnancy, and can change dramatically over time. (See "Geriatric trauma: Initial evaluation and management" and "Initial evaluation and management of blunt abdominal trauma in adults" and "Initial evaluation and management of pregnant women with major trauma".)

Rectum and genitourinary — Inspect the perineum of all patients for signs of injury. (See "Straddle injuries in children: Evaluation and management".)

Traditionally, the digital rectal examination (DRE) was considered an essential part of the physical examination for all trauma patients. However, the sensitivity of the DRE for injuries of the spinal cord, pelvis, and bowel is poor, and false positive and negative results are common [115,124-126]. Thus, routine performance is unnecessary and generally unhelpful. The examination is warranted in cases where urethral injury or penetrating rectal injury is suspected. If the examination is performed, check for the presence of gross blood (sign of bowel injury), a high-riding prostate (sign of urethral injury), abnormal sphincter tone (sign of spinal cord injury), and bone fragments (sign of pelvic fracture). (See "Blunt genitourinary trauma: Initial evaluation and management" and "Penetrating trauma of the upper and lower genitourinary tract: Initial evaluation and management" and "Evaluation and acute management of cervical spinal column injuries in adults", section on 'Secondary survey' and "Pelvic trauma: Initial evaluation and management".)

Perform a vaginal examination on all patients at risk for vaginal injury (eg, those with lower abdominal pain, pelvic fracture, or perineal laceration) [25]. Take care to avoid injury from bone fragments if a pelvic fracture is known or suspected.

Musculoskeletal — Inspect and palpate the entire length of all four extremities looking for areas of tenderness, deformity, or decreased range of motion. Also assess and document the neurovascular status of each extremity. Manipulate all joints thought to be uninjured both passively and actively to verify their integrity; immobilize and obtain radiographs of any area with a suspected fracture.

Note all penetrating wounds, especially those overlying suspected fractures, suggesting an open injury. The treatment of open fractures includes irrigation and debridement, application of a clean dressing, and prophylactic antibiotics. Preliminary low-pressure wound irrigation can be performed in the trauma bay, but definitive irrigation and debridement is performed in the operating room (OR). (See "Treatment and prevention of osteomyelitis following trauma in adults".)

Post traumatic compartment syndrome is an important source of patient morbidity. Increasing pain, tense compartments, and pain with passive stretching of the muscles contained within the compartment should prompt immediate measurement of intracompartmental pressures. (See "Acute compartment syndrome of the extremities".)

Inspect and palpate the pelvis. Ecchymosis over the pelvis or tenderness along the pelvic ring warrants diagnostic imaging. Examination findings (eg, instability) or imaging studies consistent with pelvic ring disruption indicate the need for pelvic immobilization and emergent orthopedic evaluation. Repeat examinations to assess pelvic stability are unnecessary and likely to exacerbate bleeding. (See "Pelvic trauma: Initial evaluation and management".)

Neurologic — The trauma patient's neurologic status can change dramatically over time (eg, from the effects of an expanding subdural hematoma). Serial examinations should be performed and carefully documented. During the secondary survey, perform a detailed assessment of the sensorimotor function of the extremities and repeat an assessment of the patient's Glasgow Coma Scale (GCS) score (table 6). (See "The detailed neurologic examination in adults".)

Skin — Examination of the skin may reveal lacerations, abrasions, ecchymosis, hematoma, or seroma formation. Look closely at areas where lesions may be missed, such as the scalp, axillary folds, perineum, and, particularly in obese patients, abdominal folds. Do not neglect examination of the back, gluteal fold, and posterior scalp. Penetrating wounds may be present anywhere. The management of skin wounds is discussed separately. (See "Clinical assessment of wounds" and "Basic principles of wound management".)

Appropriate tetanus prophylaxis should be given as appropriate to patients with breaks in their skin (table 7). (See "Infectious complications of puncture wounds", section on 'Tetanus immunization'.)

Additional imaging

Plain radiographs — Plain radiographs are used during the secondary survey primarily to evaluate the spine, pelvis, and extremities for fractures, dislocations, and foreign bodies.

Computed tomography, including total body CT — Multidetector computed tomography (MDCT) has become the modality of choice for imaging trauma patients because of its speed and accuracy. However, most studies of comprehensive whole body CT scanning ("pan scan") for all patients with significant trauma are methodologically limited, and have reached contradictory conclusions [127-136]. Pending further research, we do not advocate comprehensive CT scanning in patients without significant alterations in mental status and believe imaging studies should be performed selectively based upon clinical assessment and the mechanism of injury. While whole body CT scanning may improve outcomes following certain high-risk trauma, such as explosions, high speed motor vehicle collisions, and falls from great heights [92,137], we believe it should not be used indiscriminately given the short-term risk of contrast-related renal injury and the long-term risk of radiation-induced cancer, as well as the substantial costs [138]. (See "Pathogenesis, clinical features, and diagnosis of contrast-induced nephropathy" and "Radiation-related risks of imaging".)

In an international, multi-center trial, adult trauma patients with evidence of severe injury were randomly assigned to either whole body CT (n = 541) or selective CT imaging (n = 542) [139]. In-hospital mortality did not differ between groups (whole body CT 86 [16 percent] versus selective CT 85 [16 percent]), nor did it differ significantly among patients with polytrauma or brain injury.

Some authors advocate whole body CT for severely injured patients with alterations in mental status. In a retrospective database analysis of 5208 patients in Japan with scores on the Glasgow Coma Scale (GCS) ranging from 3 to 12, decreased mortality was noted in patients who received whole body CT scans [140]. Although further study of the outcomes and cost effectiveness of whole body CT is needed, the approach may be beneficial in such patients, in whom examination findings are often limited or unclear.

It should be noted that while CT may be useful in the evaluation of patients with blunt trauma [141], it has limited utility for evaluating the trajectory and effects of low velocity penetrating injury (eg, stab wounds) because of the lack of tissue disruption and gas dispersion (seen with high velocity injuries) [142], and because injuries to luminal structures are often difficult to detect [143]. Diagnostic laparoscopy may be useful in patients with penetrating injury and signs of peritoneal penetration despite negative CT imaging. Although improving, the accuracy of CT for detecting diaphragm injuries is also limited, and depending on the nature of the patient’s injuries additional diagnostic studies may be needed. The use of CT for specific injuries is discussed in detail separately, including topics devoted to particular injuries. (See "Initial evaluation and management of abdominal stab wounds in adults" and "Initial evaluation and management of abdominal gunshot wounds in adults" and "Pelvic trauma: Initial evaluation and management" and "Recognition and management of diaphragmatic injury in adults".)

Most patients should be hemodynamically stable before CT imaging is performed, and resuscitation should be sufficient to minimize the risk of decompensation while the patient is in the CT scanner. If the patient is unstable, CT imaging is usually deferred. (See 'Emergency computed tomography (CT)' above.)

PITFALLS AND PEARLS — The systematic evaluation of the trauma patient outlined above is designed to help clinicians focus on life-threatening problems and minimize the risk of missed injuries. Nevertheless, one systematic review noted that up to 39 percent of trauma patients have injuries that are initially missed and up to 22 percent of these missed injuries are clinically significant (defined as injuries associated with increased mortality, requiring additional procedures or alterations in treatment, or resulting in significant pain, complications, or residual disability) [75].

Potential pitfalls in trauma management and ways to avoid them are discussed below:

Esophageal intubations — Between 0.5 and 6 percent of prehospital intubations are esophageal due to airway difficulty or displacement during transport. Verify the position of all endotracheal tubes either by direct visualization or use of an end-tidal carbon dioxide (ETCO2) detector. (See "Prehospital care of the adult trauma patient", section on 'Airway support'.)

Hemorrhagic shock — Approximately 30 percent of the circulating blood volume may be lost before the onset of hypotension [25]. A transient response to one or more fluid boluses means the patient likely has ongoing hemorrhage and is in a persistent state of shock. A high index of suspicion should be maintained and an aggressive search for the source of ongoing hemorrhage is warranted. (See "Initial evaluation of shock in the adult trauma patient and management of NON-hemorrhagic shock".)

Cardiac tamponade — Assume that elevated jugular venous pressure (JVP) in a trauma patient is caused by pericardial tamponade. However, hypovolemic patients with tamponade may not have elevated JVP. Perform the FAST exam early in the circulation evaluation of the unstable patient and begin by looking at the heart. (See "Cardiac tamponade".)

Thoracoabdominal injury — Assume that any penetrating wound of the thorax or abdomen involves both compartments until proven otherwise.

Penetrating bowel injury — During the initial resuscitation, injuries caused by low velocity penetrating wounds (typically stab wounds) are easily missed by both ultrasound, because there is too little intraperitoneal blood to be detected, and CT, because there is inadequate tissue destruction. For stab wounds, high clinical suspicion may warrant further evaluation by DPL or laparotomy, despite initially negative imaging studies. Alternatively, a trauma surgeon may opt to perform serial observations of patients with abdominal stab wounds (and some extraperitoneal gunshot wounds) over a 12 to 24 hour period.

Gunshot wounds typically require therapeutic laparotomy and should be distinguished from the aforementioned stab wounds – these high velocity injuries are associated with a much greater morbidity and mortality than their low velocity counterparts. (See "Initial evaluation and management of abdominal gunshot wounds in adults" and "Initial evaluation and management of abdominal stab wounds in adults".)

Open book pelvic fractures — The unstable pelvis should not be manipulated multiple times; additional manipulation exacerbates hemorrhage. Once suspected, open or unstable pelvic fractures should be stabilized using a pelvic binder, or a sheet if no binder is available. If the patient is hemodynamically stable, computed tomography (CT) imaging is obtained. The unstable patient requires either surgery or angiography. (See "Pelvic trauma: Initial evaluation and management".)

Ocular injuries — Periorbital swelling and ecchymosis does not preclude performing an ocular examination. Patients with such findings are at higher risk of ocular injury. In addition, injuries such as a globe rupture or retro-orbital hematoma must be diagnosed quickly in order to maximize the opportunity to salvage vision. (See "Overview of eye injuries in the emergency department" and "Approach to eye injuries in the emergency department" and "Open globe injuries: Emergency evaluation and initial management" and "Orbital fractures" and "Retinal detachment" and "Traumatic hyphema: Clinical features and diagnosis".)

Elder patients — Assume that older patients involved in trauma have sustained a significant injury, even if they appear well. The paradox of elder trauma patients is that their physiology and medical interventions can both mask and exacerbate the severity of injuries. Medications are but one example: beta blockers may mask the effects of shock by suppressing tachycardia, while warfarin and other anticoagulants increase the risk of severe hemorrhage. A table summarizing important considerations in the elder trauma patient is attached (table 8). (See "Geriatric trauma: Initial evaluation and management".)

Common cognitive errors — Several cognitive errors appear to be relatively common during the initial management of injured patients, particularly those who do not look sick initially. Among these are [34]:

Premature diagnosis – The hemodynamic status of trauma patients is often dynamic and the results of their initial diagnostic studies preliminary. Avoid making premature assumptions about patients' injuries and stability.

Overreliance upon early negative results – No study is perfect and initial studies may not reveal the full extent of a patient's injuries or indeed any injury. Reassess the patient. Reevaluation may include serial eFAST examinations if the patient’s status has changed.

Attributing abnormal findings to benign causes – Trauma patients, particularly young healthy adults, may not immediately manifest signs of severe injury. When abnormal findings arise, assume they reflect injury.

Distractions – Dramatic or obvious injuries, performance of critical procedures, and other aspects of trauma care can distract clinicians, causing them to neglect serious but less apparent injuries or changes in patient status.

Analgesia and sedation — Injured patients are in pain. Do not neglect to provide them with appropriate analgesia and sedation. Short-acting agents, such as fentanyl and midazolam, are generally preferred to avoid adverse hemodynamic effects, but these require more frequent monitoring and administration. (See "Pain control in the critically ill adult patient" and "Management of acute perioperative pain".)

Victims of crime — Clinical evaluation and treatment of injuries is the foremost responsibility of the clinician caring for a trauma patient. When possible, caretakers should consider and act on the need to preserve potential evidence if the trauma may be connected to a crime. As examples, placing removed clothing into paper bags, avoiding cutting through holes in clothing created by penetrating injuries, and careful documentation of injuries may all be significant.


Trauma is a leading cause of mortality globally. All trauma patients require a systematic approach to management in order to maximize outcomes and reduce the risk of undiscovered injuries. Optimal care requires effective and efficient communication and teamwork among clinicians. Common breakdowns in team management are described in the text. (See 'Epidemiology' above and 'Trauma team' above.)

Particular mechanisms predispose patients to specific injuries. Common blunt trauma mechanisms and their most frequently associated injuries are described in the accompanying table (table 1).

The primary survey used in Advanced Trauma Life Support™ is organized according to the injuries that pose the most immediate threats to life. Problems are managed immediately in the order they are detected. The individual steps (including assessments of the airway, breathing, circulation, and neurologic injury) and important principles of the primary survey are described in the text. (See 'Primary evaluation and management' above.)

Observational studies suggest that airway obstruction is a major cause of preventable death among trauma patients. Therefore, airway evaluation and management remain the critical first steps in the treatment of any severely injured patient. (See 'Airway' above and 'Breathing and ventilation' above.)

Hemorrhage is the most common preventable cause of mortality in trauma. Most trauma patients with signs of shock (eg, pale, cool, moist skin) are bleeding. Be alert for subtle signs of hemorrhagic shock, particularly in the elderly and young, healthy adults who may not present with obvious manifestations. Hypotension generally does not manifest until at least 30 percent of the patient's blood volume has been lost. (See 'Circulation' above.)

Diagnostic testing plays an important role in trauma management. The appropriate use of studies is described in the text. (See 'Diagnostic studies' above.)

Clinicians at hospitals with limited resources for trauma management should consult the nearest trauma center as soon as it becomes apparent that a patient has sustained injuries beyond the management capacity of their hospital. It cannot be overemphasized that a complete workup is not a requirement for transfer. (See 'Patient transfer' above.)

A secondary survey is performed in all trauma patients determined to be stable upon completion of the primary survey. The secondary survey includes a detailed history, a thorough but efficient physical examination, and targeted diagnostic studies, and plays a crucial role in avoiding missed injuries. The secondary survey is described in detail above. (See 'Secondary evaluation' above.)

Up to 39 percent of trauma patients have injuries that are initially missed, and up to 22 percent of these are clinically significant. Common pitfalls and guidance for avoiding missed injuries are provided in the text. (See 'Pitfalls and pearls' above.)

Use of UpToDate is subject to the  Subscription and License Agreement.


  1. World Health Organization. Global burden of disease. www.who.int/healthinfo/global_burden_disease/en/ (Accessed on May 01, 2010).
  2. Feliciano, DV, Mattox, et al. Trauma, 6th, McGraw-Hill, New York 2008.
  3. CDC. National estimates of the ten leading causes of nonfatal injuries, Centers for Disease Control and Prevention 2004. www.cdc.gov/injury/wisqars.html (Accessed on May 24, 2010).
  4. Mackenzie EJ, Rivara FP, Jurkovich GJ, et al. The National Study on Costs and Outcomes of Trauma. J Trauma 2007; 63:S54.
  5. Global Status on Road Safety 2015, World Health Organization, http://www.who.int/violence_injury_prevention/road_safety_status/2015/ (Accessed on April 04, 2016).
  6. Søreide K. Epidemiology of major trauma. Br J Surg 2009; 96:697.
  7. Demetriades D, Murray J, Sinz B, et al. Epidemiology of major trauma and trauma deaths in Los Angeles County. J Am Coll Surg 1998; 187:373.
  8. Evans JA, van Wessem KJ, McDougall D, et al. Epidemiology of traumatic deaths: comprehensive population-based assessment. World J Surg 2010; 34:158.
  9. MacKenzie EJ, Rivara FP, Jurkovich GJ, et al. A national evaluation of the effect of trauma-center care on mortality. N Engl J Med 2006; 354:366.
  10. Christmas AB, Reynolds J, Wilson AK, et al. Morbid obesity impacts mortality in blunt trauma. Am Surg 2007; 73:1122.
  11. Clement ND, Tennant C, Muwanga C. Polytrauma in the elderly: predictors of the cause and time of death. Scand J Trauma Resusc Emerg Med 2010; 18:26.
  12. Perdue PW, Watts DD, Kaufmann CR, Trask AL. Differences in mortality between elderly and younger adult trauma patients: geriatric status increases risk of delayed death. J Trauma 1998; 45:805.
  13. Bamvita JM, Bergeron E, Lavoie A, et al. The impact of premorbid conditions on temporal pattern and location of adult blunt trauma hospital deaths. J Trauma 2007; 63:135.
  14. Shoko T, Shiraishi A, Kaji M, Otomo Y. Effect of pre-existing medical conditions on in-hospital mortality: analysis of 20,257 trauma patients in Japan. J Am Coll Surg 2010; 211:338.
  15. Ditillo M, Pandit V, Rhee P, et al. Morbid obesity predisposes trauma patients to worse outcomes: a National Trauma Data Bank analysis. J Trauma Acute Care Surg 2014; 76:176.
  16. Donnelly JP, Griffin RL, Sathiakumar N, McGwin G Jr. Obesity and vehicle type as risk factors for injury caused by motor vehicle collision. J Trauma Acute Care Surg 2014; 76:1116.
  17. Hwabejire JO, Kaafarani HM, Lee J, et al. Patterns of injury, outcomes, and predictors of in-hospital and 1-year mortality in nonagenarian and centenarian trauma patients. JAMA Surg 2014; 149:1054.
  18. Liu T, Chen JJ, Bai XJ, et al. The effect of obesity on outcomes in trauma patients: a meta-analysis. Injury 2013; 44:1145.
  19. Perel P, Prieto-Merino D, Shakur H, et al. Predicting early death in patients with traumatic bleeding: development and validation of prognostic model. BMJ 2012; 345:e5166.
  20. Dossett LA, Riesel JN, Griffin MR, Cotton BA. Prevalence and implications of preinjury warfarin use: an analysis of the National Trauma Databank. Arch Surg 2011; 146:565.
  21. Teixeira PG, Inaba K, Hadjizacharia P, et al. Preventable or potentially preventable mortality at a mature trauma center. J Trauma 2007; 63:1338.
  22. Teixeira PG, Inaba K, Salim A, et al. Preventable morbidity at a mature trauma center. Arch Surg 2009; 144:536.
  23. Demetriades D, Kimbrell B, Salim A, et al. Trauma deaths in a mature urban trauma system: is "trimodal" distribution a valid concept? J Am Coll Surg 2005; 201:343.
  24. Demetriades D, Murray J, Charalambides K, et al. Trauma fatalities: time and location of hospital deaths. J Am Coll Surg 2004; 198:20.
  25. American College of Surgeons Committee on Trauma. Advanced Trauma Life Support (ATLS) Student Course Manual, 9th ed, American College of Surgeons, Chicago 2012.
  26. Kotwal RS, Howard JT, Orman JA, et al. The Effect of a Golden Hour Policy on the Morbidity and Mortality of Combat Casualties. JAMA Surg 2016; 151:15.
  27. Newgard CD, Schmicker RH, Hedges JR, et al. Emergency medical services intervals and survival in trauma: assessment of the "golden hour" in a North American prospective cohort. Ann Emerg Med 2010; 55:235.
  28. Newgard CD, Meier EN, Bulger EM, et al. Revisiting the "Golden Hour": An Evaluation of Out-of-Hospital Time in Shock and Traumatic Brain Injury. Ann Emerg Med 2015; 66:30.
  29. Palanca S, Taylor DM, Bailey M, Cameron PA. Mechanisms of motor vehicle accidents that predict major injury. Emerg Med (Fremantle) 2003; 15:423.
  30. Lerner EB, Shah MN, Cushman JT, et al. Does mechanism of injury predict trauma center need? Prehosp Emerg Care 2011; 15:518.
  31. Haider AH, Chang DC, Haut ER, et al. Mechanism of injury predicts patient mortality and impairment after blunt trauma. J Surg Res 2009; 153:138.
  32. Conroy C, Tominaga GT, Erwin S, et al. The influence of vehicle damage on injury severity of drivers in head-on motor vehicle crashes. Accid Anal Prev 2008; 40:1589.
  33. Helmreich R, Musson D, Sexton J. Human factors and safety in surgery. In: Surgical Patient Safety: Essential Information for Surgeons in Today's Environment, 1st ed, Manuel B, Nora P (Eds), American College of Surgeons, Chicago 2004.
  34. Mackersie RC. Pitfalls in the evaluation and resuscitation of the trauma patient. Emerg Med Clin North Am 2010; 28:1.
  35. Kaufman EJ, Richmond TS, Wiebe DJ, et al. Patient Experiences of Trauma Resuscitation. JAMA Surg 2017; 152:843.
  36. Kirkpatrick AW, Ball CG, D'Amours SK, Zygun D. Acute resuscitation of the unstable adult trauma patient: bedside diagnosis and therapy. Can J Surg 2008; 51:57.
  37. Seamon MJ, Feather C, Smith BP, et al. Just one drop: the significance of a single hypotensive blood pressure reading during trauma resuscitations. J Trauma 2010; 68:1289.
  38. Lipsky AM, Gausche-Hill M, Henneman PL, et al. Prehospital hypotension is a predictor of the need for an emergent, therapeutic operation in trauma patients with normal systolic blood pressure in the emergency department. J Trauma 2006; 61:1228.
  39. Chesnut RM, Marshall LF, Klauber MR, et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993; 34:216.
  40. Hussain LM, Redmond AD. Are pre-hospital deaths from accidental injury preventable? BMJ 1994; 308:1077.
  41. Esposito TJ, Sanddal ND, Hansen JD, Reynolds S. Analysis of preventable trauma deaths and inappropriate trauma care in a rural state. J Trauma 1995; 39:955.
  42. Smith KA, High K, Collins SP, Self WH. A preprocedural checklist improves the safety of emergency department intubation of trauma patients. Acad Emerg Med 2015; 22:989.
  43. Conroy MJ, Weingart GS, Carlson JN. Impact of checklists on peri-intubation care in ED trauma patients. Am J Emerg Med 2014; 32:541.
  44. Tobin JM, Grabinsky A, McCunn M, et al. A checklist for trauma and emergency anesthesia. Anesth Analg 2013; 117:1178.
  45. Sherren PB, Tricklebank S, Glover G. Development of a standard operating procedure and checklist for rapid sequence induction in the critically ill. Scand J Trauma Resusc Emerg Med 2014; 22:41.
  46. Walls, RM, Murphy, MM. Manual of Emergency Airway Management, 3rd, Lippincott Williams & Wilkins, Philadelphia 2008.
  47. Brown CA 3rd, Bair AE, Pallin DJ, et al. Improved glottic exposure with the Video Macintosh Laryngoscope in adult emergency department tracheal intubations. Ann Emerg Med 2010; 56:83.
  48. Raja AS, Sullivan AF, Pallin DJ, et al. Adoption of video laryngoscopy in Massachusetts emergency departments. J Emerg Med 2012; 42:233.
  49. Strube P, Jarvis J. Experience with a patient having multiple gunshot wounds in combat. AANA J 2008; 76:11.
  50. Thiboutot F, Nicole PC, Trépanier CA, et al. Effect of manual in-line stabilization of the cervical spine in adults on the rate of difficult orotracheal intubation by direct laryngoscopy: a randomized controlled trial. Can J Anaesth 2009; 56:412.
  51. Green RS, Butler MB, Erdogan M. Increased mortality in trauma patients who develop post-intubation hypotension. J Trauma Acute Care Surg 2017.
  52. Vanderlan WB, Tew BE, McSwain NE Jr. Increased risk of death with cervical spine immobilisation in penetrating cervical trauma. Injury 2009; 40:880.
  53. Brimacombe J, Keller C, Künzel KH, et al. Cervical spine motion during airway management: a cinefluoroscopic study of the posteriorly destabilized third cervical vertebrae in human cadavers. Anesth Analg 2000; 91:1274.
  54. Donaldson WF 3rd, Heil BV, Donaldson VP, Silvaggio VJ. The effect of airway maneuvers on the unstable C1-C2 segment. A cadaver study. Spine (Phila Pa 1976) 1997; 22:1215.
  55. Gerling MC, Davis DP, Hamilton RS, et al. Effects of cervical spine immobilization technique and laryngoscope blade selection on an unstable cervical spine in a cadaver model of intubation. Ann Emerg Med 2000; 36:293.
  56. Hastings RH, Kelley SD. Neurologic deterioration associated with airway management in a cervical spine-injured patient. Anesthesiology 1993; 78:580.
  57. Liang BA, Cheng MA, Tempelhoff R. Efforts at intubation: cervical injury in an emergency circumstance? J Clin Anesth 1999; 11:349.
  58. Muckart DJ, Bhagwanjee S, van der Merwe R. Spinal cord injury as a result of endotracheal intubation in patients with undiagnosed cervical spine fractures. Anesthesiology 1997; 87:418.
  59. Raja AS, Jacobus CH. How accurate is ultrasonography for excluding pneumothorax? Ann Emerg Med 2013; 61:207.
  60. Zengerink I, Brink PR, Laupland KB, et al. Needle thoracostomy in the treatment of a tension pneumothorax in trauma patients: what size needle? J Trauma 2008; 64:111.
  61. Ahmed N, Greenberg P, Johnson VM, Davis JM. Risk stratification of survival in injured patients with cardiopulmonary resuscitation within the first hour of arrival to trauma centre: retrospective analysis from the national trauma data bank. Emerg Med J 2017; 34:282.
  62. Reisfeld RA. Pre-clinical models for immunotherapy of melanoma. Prog Clin Biol Res 1989; 288:183.
  63. Brenner M, Teeter W, Hoehn M, et al. Use of Resuscitative Endovascular Balloon Occlusion of the Aorta for Proximal Aortic Control in Patients With Severe Hemorrhage and Arrest. JAMA Surg 2017.
  64. Boulanger L, Joshi AV, Tortella BJ, et al. Excess mortality, length of stay, and costs associated with serious hemorrhage among trauma patients: findings from the National Trauma Data Bank. Am Surg 2007; 73:1269.
  65. Ley EJ, Clond MA, Srour MK, et al. Emergency department crystalloid resuscitation of 1.5 L or more is associated with increased mortality in elderly and nonelderly trauma patients. J Trauma 2011; 70:398.
  66. Cannon JW, Khan MA, Raja AS, et al. Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg 2017; 82:605.
  67. Davis JW, Davis IC, Bennink LD, et al. Are automated blood pressure measurements accurate in trauma patients? J Trauma 2003; 55:860.
  68. Callaway DW, Shapiro NI, Donnino MW, et al. Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. J Trauma 2009; 66:1040.
  69. Edelman DA, White MT, Tyburski JG, Wilson RF. Post-traumatic hypotension: should systolic blood pressure of 90-109 mmHg be included? Shock 2007; 27:134.
  70. Eastridge BJ, Salinas J, McManus JG, et al. Hypotension begins at 110 mm Hg: redefining "hypotension" with data. J Trauma 2007; 63:291.
  71. Oyetunji TA, Chang DC, Crompton JG, et al. Redefining hypotension in the elderly: normotension is not reassuring. Arch Surg 2011; 146:865.
  72. Tasaki O, Shiozaki T, Hamasaki T, et al. Prognostic indicators and outcome prediction model for severe traumatic brain injury. J Trauma 2009; 66:304.
  73. Koskinen LOD, Olivecrona M, Rodling-Wahlström M, Naredi S. Initial GCS is an unreliable predictor of outcome in patients with severe head injury treated (sTBI) by an ICP targeted therapy. A prospective study: P 070. Eur J Anaesthesiol 2008; 25:24.
  74. Foreman BP, Caesar RR, Parks J, et al. Usefulness of the abbreviated injury score and the injury severity score in comparison to the Glasgow Coma Scale in predicting outcome after traumatic brain injury. J Trauma 2007; 62:946.
  75. Pfeifer R, Pape HC. Missed injuries in trauma patients: A literature review. Patient Saf Surg 2008; 2:20.
  76. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma 2008; 65:748.
  77. Beilman GJ, Blondet JJ, Nelson TR, et al. Early hypothermia in severely injured trauma patients is a significant risk factor for multiple organ dysfunction syndrome but not mortality. Ann Surg 2009; 249:845.
  78. Nesbitt M, Allen P, Beekley A, et al. Current practice of thermoregulation during the transport of combat wounded. J Trauma 2010; 69 Suppl 1:S162.
  79. MacDonald RL, Schwartz ML, Mirich D, et al. Diagnosis of cervical spine injury in motor vehicle crash victims: how many X-rays are enough? J Trauma 1990; 30:392.
  80. Zabel DD, Tinkoff G, Wittenborn W, et al. Adequacy and efficacy of lateral cervical spine radiography in alert, high-risk blunt trauma patient. J Trauma 1997; 43:952.
  81. Fisher A, Young WF. Is the lateral cervical spine x-ray obsolete during the initial evaluation of patients with acute trauma? Surg Neurol 2008; 70:53.
  82. Wisbach GG, Sise MJ, Sack DI, et al. What is the role of chest X-ray in the initial assessment of stable trauma patients? J Trauma 2007; 62:74.
  83. Duane TM, Dechert T, Wolfe LG, et al. Clinical examination is superior to plain films to diagnose pelvic fractures compared to CT. Am Surg 2008; 74:476.
  84. Traub M, Stevenson M, McEvoy S, et al. The use of chest computed tomography versus chest X-ray in patients with major blunt trauma. Injury 2007; 38:43.
  85. Kessel B, Sevi R, Jeroukhimov I, et al. Is routine portable pelvic X-ray in stable multiple trauma patients always justified in a high technology era? Injury 2007; 38:559.
  86. Hilty MP, Behrendt I, Benneker LM, et al. Pelvic radiography in ATLS algorithms: A diminishing role? World J Emerg Surg 2008; 3:11.
  87. Soto JR, Zhou C, Hu D, et al. Skip and save: utility of pelvic x-rays in the initial evaluation of blunt trauma patients. Am J Surg 2015; 210:1076.
  88. Helling TS, Wilson J, Augustosky K. The utility of focused abdominal ultrasound in blunt abdominal trauma: a reappraisal. Am J Surg 2007; 194:728.
  89. Melniker LA. The value of focused assessment with sonography in trauma examination for the need for operative intervention in blunt torso trauma: a rebuttal to “emergency ultrasound-based algorithms for diagnosing blunt abdominal trauma (review)”, from the Cochrane Collaboration. Crit Ultrasound J 2009; 1:73.
  90. Ollerton JE, Sugrue M, Balogh Z, et al. Prospective study to evaluate the influence of FAST on trauma patient management. J Trauma 2006; 60:785.
  91. Körner M, Krötz MM, Degenhart C, et al. Current Role of Emergency US in Patients with Major Trauma. Radiographics 2008; 28:225.
  92. Raja AS, Propper BW, Vandenberg SL, et al. Imaging utilization during explosive multiple casualty incidents. J Trauma 2010; 68:1421.
  93. Plurad DS, Chiu W, Raja AS, et al. Monitoring Modalities and Assessment of Fluid Status: A Practice Management Guideline from the Eastern Association for the Surgery of Trauma (EAST). J Trauma Acute Care Surg 2017.
  94. Kirkpatrick AW, Sirois M, Laupland KB, et al. Hand-held thoracic sonography for detecting post-traumatic pneumothoraces: the Extended Focused Assessment with Sonography for Trauma (EFAST). J Trauma 2004; 57:288.
  95. Brockow K, Ring J. Anaphylaxis to radiographic contrast media. Curr Opin Allergy Clin Immunol 2011; 11:326.
  96. Zaman SR. Previous iodinated contrast anaphylaxis in blunt abdominal trauma: management options. BMJ Case Rep 2012; 2012.
  97. Danne PD, Piasio M, Champion HR. Early management of abdominal trauma: the role of diagnostic peritoneal lavage. Aust N Z J Surg 1988; 58:879.
  98. Tasse JL, Janzen ML, Ahmed NA, Chung RS. Screening laboratory and radiology panels for trauma patients have low utility and are not cost effective. J Trauma 2008; 65:1114.
  99. Asimos AW, Gibbs MA, Marx JA, et al. Value of point-of-care blood testing in emergent trauma management. J Trauma 2000; 48:1101.
  100. Sloan EP, Zalenski RJ, Smith RF, et al. Toxicology screening in urban trauma patients: drug prevalence and its relationship to trauma severity and management. J Trauma 1989; 29:1647.
  101. Husain FA, Martin MJ, Mullenix PS, et al. Serum lactate and base deficit as predictors of mortality and morbidity. Am J Surg 2003; 185:485.
  102. Paladino L, Sinert R, Wallace D, et al. The utility of base deficit and arterial lactate in differentiating major from minor injury in trauma patients with normal vital signs. Resuscitation 2008; 77:363.
  103. Odom SR, Howell MD, Silva GS, et al. Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg 2013; 74:999.
  104. Baxter J, Cranfield KR, Clark G, et al. Do lactate levels in the emergency department predict outcome in adult trauma patients? A systematic review. J Trauma Acute Care Surg 2016; 81:555.
  105. Martin MJ, FitzSullivan E, Salim A, et al. Discordance between lactate and base deficit in the surgical intensive care unit: which one do you trust? Am J Surg 2006; 191:625.
  106. Davis JW, Mackersie RC, Holbrook TL, Hoyt DB. Base deficit as an indicator of significant abdominal injury. Ann Emerg Med 1991; 20:842.
  107. Davis JW, Kaups KL, Parks SN. Base deficit is superior to pH in evaluating clearance of acidosis after traumatic shock. J Trauma 1998; 44:114.
  108. Schnüriger B, Inaba K, Barmparas G, et al. Serial white blood cell counts in trauma: do they predict a hollow viscus injury? J Trauma 2010; 69:302.
  109. Zhou Q, Rosengart MR, Billiar TR, et al. Factors Associated With Nontransfer in Trauma Patients Meeting American College of Surgeons' Criteria for Transfer at Nontertiary Centers. JAMA Surg 2017; 152:369.
  110. Nirula R, Maier R, Moore E, et al. Scoop and run to the trauma center or stay and play at the local hospital: hospital transfer's effect on mortality. J Trauma 2010; 69:595.
  111. Sampalis JS, Denis R, Fréchette P, et al. Direct transport to tertiary trauma centers versus transfer from lower level facilities: impact on mortality and morbidity among patients with major trauma. J Trauma 1997; 43:288.
  112. Enderson BL, Maull KI. Missed injuries. The trauma surgeon's nemesis. Surg Clin North Am 1991; 71:399.
  113. Houshian S, Larsen MS, Holm C. Missed injuries in a level I trauma center. J Trauma 2002; 52:715.
  114. Brooks A, Holroyd B, Riley B. Missed injury in major trauma patients. Injury 2004; 35:407.
  115. Shlamovitz GZ, Mower WR, Bergman J, et al. Poor test characteristics for the digital rectal examination in trauma patients. Ann Emerg Med 2007; 50:25.
  116. Ferraris VA, Bernard AC, Hyde B. The impact of antiplatelet drugs on trauma outcomes. J Trauma Acute Care Surg 2012; 73:492.
  117. Beynon C, Hertle DN, Unterberg AW, Sakowitz OW. Clinical review: Traumatic brain injury in patients receiving antiplatelet medication. Crit Care 2012; 16:228.
  118. Nishijima DK, Offerman SR, Ballard DW, et al. Immediate and delayed traumatic intracranial hemorrhage in patients with head trauma and preinjury warfarin or clopidogrel use. Ann Emerg Med 2012; 59:460.
  119. Joseph B, Khalil M, Zangbar B, et al. Prevalence of Domestic Violence Among Trauma Patients. JAMA Surg 2015; 150:1177.
  120. Haydel MJ, Preston CA, Mills TJ, et al. Indications for computed tomography in patients with minor head injury. N Engl J Med 2000; 343:100.
  121. Stiell IG, Wells GA, Vandemheen K, et al. The Canadian CT Head Rule for patients with minor head injury. Lancet 2001; 357:1391.
  122. Easter JS, Haukoos JS, Meehan WP, et al. Will Neuroimaging Reveal a Severe Intracranial Injury in This Adult With Minor Head Trauma?: The Rational Clinical Examination Systematic Review. JAMA 2015; 314:2672.
  123. Rodriguez RM, Anglin D, Langdorf MI, et al. NEXUS chest: validation of a decision instrument for selective chest imaging in blunt trauma. JAMA Surg 2013; 148:940.
  124. Esposito TJ, Ingraham A, Luchette FA, et al. Reasons to omit digital rectal exam in trauma patients: no fingers, no rectum, no useful additional information. J Trauma 2005; 59:1314.
  125. Guldner GT, Brzenski AB. The sensitivity and specificity of the digital rectal examination for detecting spinal cord injury in adult patients with blunt trauma. Am J Emerg Med 2006; 24:113.
  126. Hankin AD, Baren JM. Should the digital rectal examination be a part of the trauma secondary survey? Ann Emerg Med 2009; 53:208.
  127. Gupta M, Schriger DL, Hiatt JR, et al. Selective use of computed tomography compared with routine whole body imaging in patients with blunt trauma. Ann Emerg Med 2011; 58:407.
  128. Salim A, Sangthong B, Martin M, et al. Whole body imaging in blunt multisystem trauma patients without obvious signs of injury: results of a prospective study. Arch Surg 2006; 141:468.
  129. Millo NZ, Plewes C, Rowe BH, Low G. Appropriateness of CT of the chest, abdomen, and pelvis in motorized blunt force trauma patients without signs of significant injury. AJR Am J Roentgenol 2011; 197:1393.
  130. Sierink JC, Saltzherr TP, Reitsma JB, et al. Systematic review and meta-analysis of immediate total-body computed tomography compared with selective radiological imaging of injured patients. Br J Surg 2012; 99 Suppl 1:52.
  131. Sise MJ, Kahl JE, Calvo RY, et al. Back to the future: reducing reliance on torso computed tomography in the initial evaluation of blunt trauma. J Trauma Acute Care Surg 2013; 74:92.
  132. Surendran A, Mori A, Varma DK, Gruen RL. Systematic review of the benefits and harms of whole-body computed tomography in the early management of multitrauma patients: are we getting the whole picture? J Trauma Acute Care Surg 2014; 76:1122.
  133. Caputo ND, Stahmer C, Lim G, Shah K. Whole-body computed tomographic scanning leads to better survival as opposed to selective scanning in trauma patients: a systematic review and meta-analysis. J Trauma Acute Care Surg 2014; 77:534.
  134. Van Vugt R, Keus F, Kool D, et al. Selective computed tomography (CT) versus routine thoracoabdominal CT for high-energy blunt-trauma patients. Cochrane Database Syst Rev 2013; :CD009743.
  135. Hajibandeh S, Hajibandeh S. Systematic review: effect of whole-body computed tomography on mortality in trauma patients. J Inj Violence Res 2015; 7:64.
  136. Long B, April MD, Summers S, Koyfman A. Whole body CT versus selective radiological imaging strategy in trauma: an evidence-based clinical review. Am J Emerg Med 2017; 35:1356.
  137. Huber-Wagner S, Lefering R, Qvick LM, et al. Effect of whole-body CT during trauma resuscitation on survival: a retrospective, multicentre study. Lancet 2009; 373:1455.
  138. Inaba K, Branco BC, Lim G, et al. The increasing burden of radiation exposure in the management of trauma patients. J Trauma 2011; 70:1366.
  139. Sierink JC, Treskes K, Edwards MJ, et al. Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial. Lancet 2016; 388:673.
  140. Kimura A, Tanaka N. Whole-body computed tomography is associated with decreased mortality in blunt trauma patients with moderate-to-severe consciousness disturbance: a multicenter, retrospective study. J Trauma Acute Care Surg 2013; 75:202.
  141. Benjamin ER, Siboni S, Haltmeier T, et al. Negative Finding From Computed Tomography of the Abdomen After Blunt Trauma. JAMA Surg 2015; 150:1194.
  142. Bonatti H, Calland JF. Trauma. Emerg Med Clin North Am 2008; 26:625.
  143. Ng AK, Simons RK, Torreggiani WC, et al. Intra-abdominal free fluid without solid organ injury in blunt abdominal trauma: an indication for laparotomy. J Trauma 2002; 52:1134.
Topic 13854 Version 59.0

Topic Outline



All topics are updated as new information becomes available. Our peer review process typically takes one to six weeks depending on the issue.