Abstract
We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
AIDS-Related Opportunistic Infections / drug therapy
-
AIDS-Related Opportunistic Infections / virology
-
Acyclovir / pharmacology
-
Adult
-
Aminoquinolines / therapeutic use*
-
Antiviral Agents / pharmacology
-
Dendritic Cells / pathology*
-
HIV Infections / complications
-
HIV Infections / immunology*
-
HIV-1 / immunology
-
Herpes Genitalis / drug therapy*
-
Herpesvirus 2, Human / drug effects
-
Humans
-
Imiquimod
-
Interferon Inducers / therapeutic use*
-
Male
Substances
-
Aminoquinolines
-
Antiviral Agents
-
Interferon Inducers
-
Imiquimod
-
Acyclovir