Abstract
Two patients with multiple organ systems failure developed seizures after receiving imipenem/cilastatin (I/C) despite dose adjustment for poor renal function. Neither patient had a past history of seizures, nor had experienced seizures after receiving high doses of other beta-lactam antibiotics. Simple dose adjustment of I/C based on low creatinine clearances may not be adequate to prevent seizures.
MeSH terms
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Aged
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / therapeutic use
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Cilastatin / administration & dosage
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Cilastatin / adverse effects
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Cilastatin / therapeutic use
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Cilastatin, Imipenem Drug Combination
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Drug Combinations
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Female
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Humans
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Imipenem / administration & dosage
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Imipenem / adverse effects*
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Imipenem / therapeutic use
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Male
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Middle Aged
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Seizures / chemically induced*
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Seizures / physiopathology
Substances
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Anti-Bacterial Agents
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Drug Combinations
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Cilastatin
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Imipenem
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Cilastatin, Imipenem Drug Combination