Seizure activity associated with imipenem use: clinical case reports and review of the literature

DICP. 1991 Apr;25(4):351-4. doi: 10.1177/106002809102500403.

Abstract

Two patients with multiple organ systems failure developed seizures after receiving imipenem/cilastatin (I/C) despite dose adjustment for poor renal function. Neither patient had a past history of seizures, nor had experienced seizures after receiving high doses of other beta-lactam antibiotics. Simple dose adjustment of I/C based on low creatinine clearances may not be adequate to prevent seizures.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Cilastatin / administration & dosage
  • Cilastatin / adverse effects
  • Cilastatin / therapeutic use
  • Cilastatin, Imipenem Drug Combination
  • Drug Combinations
  • Female
  • Humans
  • Imipenem / administration & dosage
  • Imipenem / adverse effects*
  • Imipenem / therapeutic use
  • Male
  • Middle Aged
  • Seizures / chemically induced*
  • Seizures / physiopathology

Substances

  • Anti-Bacterial Agents
  • Drug Combinations
  • Cilastatin
  • Imipenem
  • Cilastatin, Imipenem Drug Combination