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IgG subclass deficiency

Alan P Knutsen, MD
Section Editor
E Richard Stiehm, MD
Deputy Editor
Anna M Feldweg, MD


The clinical presentation, pathogenesis, diagnosis, and treatment of immunoglobulin G (IgG) subclass deficiency are presented here. The physical and biologic properties of IgG subclasses are reviewed separately. (See "IgG subclasses: Physical properties, genetics, and biologic functions".)


The term "IgG subclass deficiency" refers to a significant decrease in the serum concentrations of one or more subclasses of IgG in a patient whose total IgG concentration is normal [1].

Clinically significant deficiency — IgG subclass deficiency is a laboratory finding that does not necessarily equate to a clinical disorder. The diagnosis of a clinically significant IgG subclass deficiency requires evidence of antibody dysfunction in the form of recurrent infections and an inadequate response to vaccine challenge.

Lower limits of normal — The normal ranges for IgG subclasses are broad and vary with the age of the population studied, presence or absence of disease, and the method of analysis (table 1) [2-9].

For children 4 to 10 years of age, levels below the following are considered abnormal:

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Literature review current through: Sep 2017. | This topic last updated: Feb 27, 2017.
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