Abstract
In fifteen patients with hyperkalaemic familial periodic paralysis, inhalation of salbutamol alleviated hyperkaleamia and paralysis precipitated by exercise or oral administration of potassium chloride. In-vitro studies with rat soleus muscles indicated that the hypokalaemic effect of salbutamol is related to stimulation of the active coupled transport of sodium and potassium in muscle cells. Follow-up studies proved that the inhalation of salbutamol is a simple and adequate method for the treatment of the paralytic episodes in these patients.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Adolescent
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Adult
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Aerosols
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Albuterol / administration & dosage*
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Albuterol / pharmacology
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Albuterol / therapeutic use
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Animals
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Clinical Trials as Topic
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Epinephrine / pharmacology
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Humans
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Hyperkalemia / chemically induced
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Hyperkalemia / complications
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Hyperkalemia / drug therapy*
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Hyperkalemia / etiology
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Middle Aged
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Muscles / metabolism
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Ouabain / pharmacology
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Paralyses, Familial Periodic / drug therapy*
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Paralyses, Familial Periodic / etiology
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Physical Exertion
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Potassium / metabolism
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Potassium Chloride / adverse effects
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Rats
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Sodium / metabolism
Substances
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Aerosols
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Ouabain
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Potassium Chloride
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Sodium
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Albuterol
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Potassium
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Epinephrine