HER2 and predicting response to therapy in breast cancer
- Hideko Yamauchi, MD
Hideko Yamauchi, MD
- Adjunct Instructor
- Department of Breast and Endocrine Surgery,
- Juntendo University School of Medicine
- Director of Breast Surgical Oncology
- Breast Center
- St. Luke's International Hospital
- Tokyo, Japan
- Daniel F Hayes, MD
Daniel F Hayes, MD
- Section Editor — Breast Cancer
- Professor of Medicine
- University of Michigan School of Medicine
Breast cancer is a heterogeneous, phenotypically diverse disease composed of several biologic subtypes that have distinct behavior. Amplification or overexpression of the human epidermal growth factor receptor 2 (HER2) oncogene is present in approximately 15 percent of primary invasive breast cancers . Women with both early-stage and metastatic breast cancer that meet criteria for HER2 positivity are treated with regimens including HER2-directed therapy.
Here we will review the definition of HER2 positivity, and the approach to HER2 discordance. Management of those with HER2-positive disease in the neoadjuvant, adjuvant, and metastatic settings, as well as treatment protocols for HER2-positive breast cancer, are discussed elsewhere:
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