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Hand-foot skin reaction induced by multitargeted tyrosine kinase inhibitors

Mario E Lacouture, MD
Beth N McLellan, MD
Section Editors
Maja Mockenhaupt, MD, PhD
Jean-Claude Roujeau, MD
Reed E Drews, MD
Deputy Editor
Rosamaria Corona, MD, DSc


Protein tyrosine kinase inhibitors (TKIs), which include selective and multikinase inhibitors, are a class of targeted anticancer medications approved for treatment of a number of solid tumors. The ability of TKIs to block molecular pathways specific to the proliferation of malignant cells has decreased the incidence of many of the adverse events caused by cytotoxic chemotherapy. However, TKIs bring their own set of specific dermatologic adverse events, which include [1]:

Hand-foot skin reaction (HFSR)

Seborrheic dermatitis-like eruption

Subungual splinter hemorrhages

Keratoacanthoma and squamous cell carcinomas

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Literature review current through: Sep 2017. | This topic last updated: Nov 29, 2016.
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