Abstract
To investigate whether the occurrence of extrapyramidal side effects was related to D2 dopamine receptor occupancy, iodobenzamide single positron emission computed tomography was carried out in 27 schizophrenic patients and 10 controls. Eighteen patients were treated with haloperidol; 9 patients were treated with clozapine. Our data suggest a relationship between D2 receptor occupancy and extrapyramidal side effects as well as the existence of a neuroleptic threshold of a striatal:frontal cortex ratio of 1.2, below which drug-induced exptrapyramidal side effects can be expected.
MeSH terms
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Adult
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Basal Ganglia Diseases / chemically induced*
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Basal Ganglia Diseases / diagnostic imaging
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Clozapine / adverse effects*
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Clozapine / therapeutic use
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Dose-Response Relationship, Drug
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Dyskinesia, Drug-Induced / diagnostic imaging*
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Extrapyramidal Tracts / diagnostic imaging
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Extrapyramidal Tracts / drug effects
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Female
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Haloperidol / adverse effects*
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Haloperidol / therapeutic use
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Humans
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Male
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Middle Aged
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Neurologic Examination / drug effects
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Receptors, Dopamine D2 / drug effects*
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Receptors, Dopamine D2 / physiology
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Schizophrenia / diagnostic imaging
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Schizophrenia / drug therapy*
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Schizophrenic Psychology*
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Tomography, Emission-Computed, Single-Photon*
Substances
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Receptors, Dopamine D2
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Clozapine
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Haloperidol