Acute high-dose parenteral haloperidol treatment of psychosis

Am J Psychiatry. 1979 Aug;136(8):1061-4. doi: 10.1176/ajp.136.8.1061.

Abstract

After 2 days of drug-free observation, 20 newly admitted psychotic patients received 20-35 mg of haloperidol intravenously and 20 patients received 30-40 mg of diazepam intravenously. Posttreatment ratings at 4 and 24 hours with the Brief Psychiatric Rating Scale and the Clinical Global Impressions revealed significant improvement in both groups but no significant differences between the two treatments.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Acute Disease
  • Adult
  • Bipolar Disorder / drug therapy
  • Blood Pressure / drug effects
  • Clinical Trials as Topic
  • Diazepam / therapeutic use
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Haloperidol / therapeutic use*
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Paranoid Disorders / drug therapy
  • Psychiatric Status Rating Scales
  • Psychotic Disorders / drug therapy*
  • Schizophrenia / drug therapy

Substances

  • Haloperidol
  • Diazepam