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Medline ® Abstract for Reference 11

of 'Guttate psoriasis'

11
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Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis.
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Wu D, Wu Y, Liu JL, Wang B, Zhang XD
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Genet Mol Res. 2011;10(4):3109-20.
 
Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations between HLA-Cw*0602 polymorphism and psoriasis risk were estimated by pooled odds ratio (OR) and 95% confidence interval (95%CI). We found significant associations between HLA-Cw*0602 polymorphism and psoriasis risk in the comparisons of positive versus negative alleles (OR = 4.55, 95%CI = 3.65-5.67, P<0.00001); positive homozygote versus negative homozygote combined with heterozygote (OR = 14.00, 95%CI = 8.47-23.15, P<0.00001); positive homozygote combined with heterozygote versus negative homozygote (OR = 5.11, 95%CI = 3.86-6.76, P<0.00001); positive homozygote versus negative homozygote (OR = 23.03, 95%CI = 13.95-38.00, P<0.00001), and positive homozygote versus heterozygote (OR = 4.21, 95%CI = 2.35- 7.00, P<0.00001). In conclusion, the positive allele of HLA-Cw*0602 polymorphism appears to be a risk factor for psoriasis.
AD
Department of Dermatology, Beihua Affiliated Hospital, Jilin, China.
PMID