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Gianotti-Crosti syndrome (papular acrodermatitis)

Antonio A T Chuh, MD, FRCP, FRCPCH
Section Editors
Moise L Levy, MD
Morven S Edwards, MD
Deputy Editor
Abena O Ofori, MD


Gianotti-Crosti syndrome (GCS), also known as papular acrodermatitis, papular acrodermatitis of childhood, and infantile papular acrodermatitis, is a symmetric papular eruption with an acral distribution (cheeks, buttocks, and extensor surfaces of the forearms and legs) (picture 1A-F). It was first described by Gianotti in 1955, and by Crosti and Gianotti in 1957 [1,2], and was initially believed to occur only in infants and children [3-5]. It has since been reported in adults [6-8].


In the original descriptions, Gianotti-Crosti syndrome (GCS) had three cardinal manifestations [1-5]:

Nonrelapsing erythemato-papular dermatitis localized to the face and limbs, lasting about three weeks

Paracortical hyperplasia of lymph nodes

Acute hepatitis, usually anicteric, which could last for months and progress to chronic liver disease

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Literature review current through: Nov 2017. | This topic last updated: Nov 20, 2017.
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