Genetic risk factors for prostate cancer
- Heather H Cheng, MD, PhD
Heather H Cheng, MD, PhD
- Assistant Professor, Division of Medical Oncology, University of Washington
- Assistant Member, Division of Clinical Research, Fred Hutchinson Cancer Research Center
- Peter S Nelson, MD
Peter S Nelson, MD
- Member, Divisions of Human Biology and Clinical Research
- Fred Hutchinson Cancer Research Center
- Professor, Division of Medical Oncology, University of Washington
- Section Editors
- Jerome P Richie, MD, FACS
Jerome P Richie, MD, FACS
- Section Editor — Cancer of the Urethra, Penis, and Ureter; Urologic Surgery; Prostate Cancer
- Elliott Carr Cutler Professor of Surgery
- Harvard Medical School
- Nicholas Vogelzang, MD
Nicholas Vogelzang, MD
- Section Editor — Prostate Cancer
- Professor of Medicine
- University of Nevada School of Medicine
- US Oncology Research
- W Robert Lee, MD, MS, MEd
W Robert Lee, MD, MS, MEd
- Section Editor — Prostate Cancer
- Professor of Radiation Oncology
- Duke University Medical Center
Prostate cancer is the most common cancer in men worldwide, with an estimated 1,600,000 cases and 366,000 deaths in 2015. Prostate cancer was the leading cause of cancer deaths for men in 29 countries .
The most important known risk factors for prostate cancer are age, ethnicity, and inherited genetic variants. The genetic risk factors for adenocarcinoma of the prostate are reviewed here. Other risk factors for prostate cancer are discussed separately. (See "Risk factors for prostate cancer".)
Prostate cancer has a strong genetic component. However, identifying specific genes that underlie the disease is challenging.
Evidence supporting the role of genetic factors comes from studies of relatives of patients with prostate cancer (linkage studies), genome-wide association studies (GWAS), patients from families with inherited mutations in known cancer predisposition genes (such as BRCA2 and BRCA1), and next-generation sequencing studies in men with metastatic prostate cancer. This observation, coupled with an association with more aggressive features, may contribute to strategies for the early detection, diagnosis, and management of prostate cancer in the context of certain deleterious variants (for example, in BRCA2) .
Contemporary studies have found a much higher prevalence of known inherited cancer predisposition genes (eg, BRCA2) than previously appreciated in men with aggressive prostate cancer. This observation may contribute to strategies for the early detection, diagnosis, and management.To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- HERITABLE FACTORS
- REFERRAL FOR GENETIC EVALUATION
- SCREENING IMPLICATIONS OF INCREASED RISK
- FAMILY STUDIES
- Impact of family history
- Impact of specific genes identified in family studies
- - HOXB13
- POPULATION STUDIES
- DNA REPAIR GENES
- BRCA2 and BRCA1
- - BRCA2
- - BRCA1
- Lynch syndrome
- Assessments of germline DNA repair gene mutations in aggressive prostate cancer
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS