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Courtney D Stephenson, DO
Charles J Lockwood, MD, MHCM
Andrew P MacKenzie, MD
Section Editors
Louise Wilkins-Haug, MD, PhD
Deborah Levine, MD
Deputy Editor
Vanessa A Barss, MD, FACOG


Gastroschisis is a full-thickness, paraumbilical abdominal wall defect usually associated with evisceration of bowel (picture 1).


Several hypotheses have been proposed to explain the pathogenesis of gastroschisis; all involve defective formation or disruption of the body wall in the embryonic period, with subsequent herniation of bowel [1]:

Failure of mesoderm to form in the body wall

Rupture of the amnion around the umbilical ring

Abnormal involution of the right umbilical vein leading to weakening of the body wall

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Literature review current through: Nov 2017. | This topic last updated: Sep 08, 2017.
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