Scleral melt following Retisert intravitreal fluocinolone implant

Drug Des Devel Ther. 2014 Nov 28:8:2373-5. doi: 10.2147/DDDT.S66634. eCollection 2014.

Abstract

Intravitreal fluocinolone acetonide implant (Retisert) has a high potency, a low solubility, and a very short duration of action in the systemic circulation, enabling the steroid pellet to be small and reducing the risk of systemic side effects. Scleral melt has not been reported as a possible complication of Retisert implant. The authors describe the occurrence of scleral melt 18 months after the implantation of fluocinolone acetonide implant in a 42-year-old Caucasian woman. To the authors' knowledge, this is the first report of this possible complication.

Keywords: Retisert; complication; scleral melt; surgical management.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Fluocinolone Acetonide / administration & dosage
  • Fluocinolone Acetonide / adverse effects*
  • Humans
  • Intravitreal Injections
  • Scleritis / drug therapy
  • Scleritis / pathology*
  • Scleritis / surgery

Substances

  • Fluocinolone Acetonide