Ventricular tachycardia after initiation of fingolimod

BMJ Case Rep. 2017 Sep 27:2017:bcr2017221819. doi: 10.1136/bcr-2017-221819.

Abstract

Fingolimod, a sphingosine-1-phosphate receptor modulator, is used for the treatment of relapsing-remitting multiple sclerosis. It is well known to cause bradyarrhythmias. We present a 63-year-old woman who was admitted to the hospital with sustained monomorphic ventricular tachycardia 2 weeks after fingolimod initiation. Further evaluation showed that the patient's ventricular tachycardia was most likely secondary to her medication. Medical practitioners need to be aware of such possible life-threatening side effects while using fingolimod.

Keywords: arrhythmias; drugs and medicines; neurology.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Electrocardiography
  • Female
  • Fingolimod Hydrochloride / adverse effects*
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Tachycardia, Ventricular / chemically induced
  • Tachycardia, Ventricular / diagnosis*
  • Tachycardia, Ventricular / physiopathology

Substances

  • Immunosuppressive Agents
  • Fingolimod Hydrochloride