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Evaluation of the endometrium for malignant or premalignant disease

Sarah Feldman, MD, MPH
Section Editors
Deborah Levine, MD
Barbara Goff, MD
Deputy Editor
Sandy J Falk, MD, FACOG


Evaluation of the endometrium is the key component in the diagnostic evaluation of women suspected of endometrial cancer or a premalignant endometrial lesion. An endometrial sampling procedure is the gold standard for diagnostic evaluation of women with abnormal uterine bleeding in whom endometrial hyperplasia or carcinoma is a possibility (table 1). (See "Endometrial sampling procedures".)


Endometrial biopsy — The development of equipment and techniques for office-based endometrial biopsy has generally replaced the need for diagnostic dilation and curettage (D&C) performed in the operating room [1]. Advantages of office biopsy include:

Minimal to no cervical dilation is required.

Local or no anesthesia is generally required.

Performing the procedure in an office setting is less expensive than a procedure in the operating room.

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Literature review current through: Nov 2017. | This topic last updated: Feb 09, 2017.
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