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Medline ® Abstract for Reference 43

of 'Epidemiology, microbiology and pathogenesis of plague (Yersinia pestis infection)'

Plague bacteria target immune cells during infection.
Marketon MM, DePaolo RW, DeBord KL, Jabri B, Schneewind O
Science. 2005;309(5741):1739. Epub 2005 Jul 28.
The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targeted for injection during plague infection is unknown. We found, using Yop beta-lactamase hybrids and fluorescent staining of live cells from plague-infected animals, that Y. pestis selected immune cells for injection. In vivo, dendritic cells, macrophages, and neutrophils were injected most frequently, whereas B and T lymphocytes were rarely selected. Thus, it appears that Y. pestis disables these cell populations to annihilate host immune responses during plague.
Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.