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Medline ® Abstract for Reference 101

of 'Epidemiology, clinical manifestations, and treatment of cytomegalovirus infection in immunocompetent adults'

Prior infection with cytomegalovirus is not a major risk factor for angiographically demonstrated coronary artery atherosclerosis.
Adler SP, Hur JK, Wang JB, Vetrovec GW
J Infect Dis. 1998;177(1):209.
To determine if cytomegalovirus (CMV) infection is a risk factor for primary coronary artery disease (CAD), the association between CMV infection and CAD (>50% blockage in any coronary artery) was investigated in nearly 900 successive nontransplant patients undergoing coronary angiography. By use of logistic regression, older age (P<.001), white race (P<.001), gender (P<.001), hypercholesterolemia (P = .04), and other established cardiovascular risk factors (P = .003) were identified as significantly associated with CAD, but CMV seropositivity (P = .462), the level of IgG antibodies to CMV whole cell antigen (P = .98), or the levels of IgG antibodies to CMV glycoprotein B (P = .67) were not. These data suggest that CMV infection is not a major risk factor for the development of primary CAD in adults.
Department of Pediatrics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0163, USA. sadler@gems.vcu.edu