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Medline ® Abstract for Reference 22

of 'Epidemiology, clinical manifestations, and diagnosis of genital herpes simplex virus infection'

Herpes simplex virus viremia during primary genital infection.
Johnston C, Magaret A, Selke S, Remington M, Corey L, Wald A
J Infect Dis. 2008;198(1):31.
Primary genital herpes simplex virus (HSV) infection is commonly associated with systemic symptoms. A systematic evaluation of HSV viremia during primary genital infection has not been performed previously. Plasma samples from adults with a first clinical episode of genital HSV infection were assayed for HSV DNA by polymerase chain reaction. One hundred sixty-four adults had confirmed primary genital HSV infection. Of these, 40 (24%) had HSV DNA detected in plasma. Thirty-seven (93%) of 40 were infected with HSV-2. Viremic participants were more likely to be women, compared with aviremic participants (83% vs. 61%; P=.01). Viremia was detected more frequently and at a higher number of copies per milliliter early in infection. We conclude that HSV viremia during primary genital HSV infection is common, especially among women.
Department of Medicine, Universityof Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. cjohnsto@u.washington.edu