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Medline ® Abstract for Reference 22

of 'Epidemiology, clinical manifestations, and diagnosis of genital herpes simplex virus infection'

22
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Herpes simplex virus viremia during primary genital infection.
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Johnston C, Magaret A, Selke S, Remington M, Corey L, Wald A
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J Infect Dis. 2008;198(1):31.
 
Primary genital herpes simplex virus (HSV) infection is commonly associated with systemic symptoms. A systematic evaluation of HSV viremia during primary genital infection has not been performed previously. Plasma samples from adults with a first clinical episode of genital HSV infection were assayed for HSV DNA by polymerase chain reaction. One hundred sixty-four adults had confirmed primary genital HSV infection. Of these, 40 (24%) had HSV DNA detected in plasma. Thirty-seven (93%) of 40 were infected with HSV-2. Viremic participants were more likely to be women, compared with aviremic participants (83% vs. 61%; P=.01). Viremia was detected more frequently and at a higher number of copies per milliliter early in infection. We conclude that HSV viremia during primary genital HSV infection is common, especially among women.
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Department of Medicine, Universityof Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. cjohnsto@u.washington.edu
PMID