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Medline ® Abstract for Reference 66

of 'Endometriosis: Treatment of rectovaginal and bowel disease'

Laparoscopic management of bowel endometriosis: resection margins as a predictor of recurrence.
Nirgianakis K, McKinnon B, Imboden S, Knabben L, Gloor B, Mueller MD
Acta Obstet Gynecol Scand. 2014 Dec;93(12):1262-7. Epub 2014 Sep 17.
OBJECTIVE: To evaluate possible predictive factors for recurrence after laparoscopic segmental bowel resection for bowel endometriosis.
DESIGN: Cohort study.
SETTING: Academic tertiary referral center.
METHODS: 95 symptomatic women with bowel endometriosis who underwent laparoscopic segmental bowel resection at the Endometriosis clinic, University of Berne, between 2002 and 2012 were enrolled. Since 14 women were lost to follow-up, 81 formed the final cohort. Clinical and histological characteristics were examined as possible predictive factors for disease recurrence.
MAIN OUTCOME MEASURES: Recurrence, defined as a subsequent operation due to recurrent endometriosis-associated pain with a histologically confirmed endometriotic lesion.
RESULTS: Recurrence was observed in 13 (16%) patients. Variables that were significantly associated to recurrence by the Cox regression analysis were positive bowel resection margins (hazard ratio 6.5, 95% confidence interval 1.8-23.5, p = 0.005), age<31 years (hazard ratio 5.6, 95% confidence interval 1.7-18.6, p = 0.005) and body mass index≥23 kg/m(2) (hazard ratio 11.0, 95% confidence interval 2.7-44.6, p = 0.001).
CONCLUSIONS: Positive bowel resection margins as well as age<31 years and body mass index≥23 kg/m(2) appear to be independent predictors of disease recurrence.
Department of Obstetrics and Gynecology, University of Berne, Berne, Switzerland.