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Disorders of fibrinogen

Caroline Bérubé, MD
Section Editor
Lawrence LK Leung, MD
Deputy Editor
Jennifer S Tirnauer, MD


Fibrinogen circulates in the plasma at a concentration of approximately 200 to 400 mg/dL, with a half-life of four days and a catabolic rate of approximately 25 percent per day [1]. Fibrinogen has numerous functional interactions and plays a pivotal role in the hemostatic balance:

It is the substrate for fibrin clot formation.

It binds to platelets to support platelet aggregation.

It has a role in wound healing.

The fibrin clot is a template for both thrombin binding and the fibrinolytic system.


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Literature review current through: Jul 2017. | This topic last updated: Aug 23, 2016.
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