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Diseases potentially acquired by travel to Central Africa

David Murdoch, MD, MSc, DTM&H, FRACP, FRCPA, FFSc(RCPA)
Section Editor
Karin Leder, MBBS, FRACP, PhD, MPH, DTMH
Deputy Editor
Elinor L Baron, MD, DTMH


Central Africa is comprised of Angola, Cameroon, Central African Republic, Chad, Congo, Equatorial Guinea, Gabon, South Sudan, Sudan, Democratic Republic of Congo (Zaire), and Zambia. This region encompasses tropical rain forests, desert areas, and wooded areas.


Malaria — Malaria is a major risk for travelers to Central Africa. Endemic areas exist in all countries in this region. Plasmodium falciparum is the predominant cause of malaria, and chloroquine resistance is widespread. Within endemic areas, transmission occurs year round [1]:

Angola – Risk throughout the year in the whole country

Cameroon – Risk throughout the year in the whole country

Central African Republic – Risk throughout the year in the whole country

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Literature review current through: Nov 2017. | This topic last updated: Aug 25, 2017.
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  1. World Health Organization. International travel and health. WHO, Geneva 2012.
  2. Informal Working Group on Geographic Risk of Yellow Fever. Background for the Consultation on Yellow Fever and International Travel, 2010 (update February 2011). World Health Organization, Stockholm, Sweden, 4-5 March 2010.
  3. Peters CJ, LeDuc JW. An introduction to Ebola: the virus and the disease. J Infect Dis 1999; 179 Suppl 1:ix.
  4. Mahanty S, Bray M. Pathogenesis of filoviral haemorrhagic fevers. Lancet Infect Dis 2004; 4:487.
  5. Heffernan RT, Pambo B, Hatchett RJ, et al. Low seroprevalence of IgG antibodies to Ebola virus in an epidemic zone: Ogooué-Ivindo region, Northeastern Gabon, 1997. J Infect Dis 2005; 191:964.
  6. Leroy EM, Kumulungui B, Pourrut X, et al. Fruit bats as reservoirs of Ebola virus. Nature 2005; 438:575.
  7. Bausch DG, Nichol ST, Muyembe-Tamfum JJ, et al. Marburg hemorrhagic fever associated with multiple genetic lineages of virus. N Engl J Med 2006; 355:909.
  8. Centers for Disease Control and Prevention (CDC). Outbreak of Marburg virus hemorrhagic fever--Angola, October 1, 2004-March 29, 2005. MMWR Morb Mortal Wkly Rep 2005; 54:308.
  9. Peters CJ. Marburg and Ebola--arming ourselves against the deadly filoviruses. N Engl J Med 2005; 352:2571.
  10. Borchert M, Mulangu S, Swanepoel R, et al. Serosurvey on household contacts of Marburg hemorrhagic fever patients. Emerg Infect Dis 2006; 12:433.
  11. Ergonul O. Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries. Curr Opin Virol 2012; 2:215.
  12. Whitehouse CA. Crimean-Congo hemorrhagic fever. Antiviral Res 2004; 64:145.
  13. Ergönül O. Crimean-Congo haemorrhagic fever. Lancet Infect Dis 2006; 6:203.
  14. Ergönül O, Celikbaş A, Dokuzoguz B, et al. Characteristics of patients with Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and impact of oral ribavirin therapy. Clin Infect Dis 2004; 39:284.
  15. Swanepoel R, Shepherd AJ, Leman PA, et al. Epidemiologic and clinical features of Crimean-Congo hemorrhagic fever in southern Africa. Am J Trop Med Hyg 1987; 36:120.
  16. Tufan ZK, Yigit H, Kacar M, et al. Sonographic findings in patients with Crimean-Congo hemorrhagic fever. J Ultrasound Med 2014; 33:1999.
  17. Shepherd AJ, Swanepoel R, Leman PA. Antibody response in Crimean-Congo hemorrhagic fever. Rev Infect Dis 1989; 11 Suppl 4:S801.
  18. Fisher-Hoch SP, Khan JA, Rehman S, et al. Crimean Congo-haemorrhagic fever treated with oral ribavirin. Lancet 1995; 346:472.
  19. Ergonul O, Tuncbilek S, Baykam N, et al. Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic fever. J Infect Dis 2006; 193:941.
  20. Ponce-de-León S, Lisker-Melman M, Kato-Maeda M, et al. Trypanosoma brucei rhodesiense infection imported to Mexico from a tourist resort in Kenya. Clin Infect Dis 1996; 23:847.
  21. Pryce D, Behrens R, Davidson R, et al. Onchocerciasis in members of an expedition to Cameroon: role of advice before travel and long term follow up. BMJ 1992; 304:1285.
  22. Encarnacion CF, Giordano MF, Murray HW. Onchocerciasis in New York City. The Moa-Manhattan connection. Arch Intern Med 1994; 154:1749.
  23. Mendelson M, Davis XM, Jensenius M, et al. Health risks in travelers to South Africa: the GeoSentinel experience and implications for the 2010 FIFA World Cup. Am J Trop Med Hyg 2010; 82:991.
  24. Parola P. Rickettsioses in sub-Saharan Africa. Ann N Y Acad Sci 2006; 1078:42.
  25. Centers for Disease Control and Prevention. Chikungunya virus - Geographic Distribution. http://www.cdc.gov/chikungunya/geo/index.html (Accessed on April 14, 2016).
  26. Jan C, Languillat G, Renaudet J, Robin Y. [A serological survey of arboviruses in Gabon]. Bull Soc Pathol Exot Filiales 1978; 71:140.
  27. Saluzzo JF, Ivanoff B, Languillat G, Georges AJ. [Serological survey for arbovirus antibodies in the human and simian populations of the South-East of Gabon (author's transl)]. Bull Soc Pathol Exot Filiales 1982; 75:262.
  28. Grard G, Caron M, Mombo IM, et al. Zika virus in Gabon (Central Africa)--2007: a new threat from Aedes albopictus? PLoS Negl Trop Dis 2014; 8:e2681.
  29. Berthet N, Nakouné E, Kamgang B, et al. Molecular characterization of three Zika flaviviruses obtained from sylvatic mosquitoes in the Central African Republic. Vector Borne Zoonotic Dis 2014; 14:862.
  30. Steffen R. Epidemiology of traveler's diarrhea. Clin Infect Dis 2005; 41 Suppl 8:S536.
  31. Hyams KC, Purdy MA, Kaur M, et al. Acute sporadic hepatitis E in Sudanese children: analysis based on a new western blot assay. J Infect Dis 1992; 165:1001.
  32. Jelinek T, Nothdurft HD, Löscher T. Schistosomiasis in Travelers and Expatriates. J Travel Med 1996; 3:160.
  33. Eng TR, O'Brien TR, Bernard KW, et al. HIV-1 and HIV-2 Infections Among U.S. Peace Corps Volunteers Returning from West Africa. J Travel Med 1995; 2:174.
  34. Cleaveland S. Royal Society of Tropical Medicine and Hygiene meeting at Manson House, London, 20 March 1997. Epidemiology and control of rabies. The growing problem of rabies in Africa. Trans R Soc Trop Med Hyg 1998; 92:131.