Diagnostic testing for HIV infection in infants and children younger than 18 months
- Susan L Gillespie, MD, PhD
Susan L Gillespie, MD, PhD
- Associate Professor of Pediatrics
- Baylor College of Medicine
Readily available diagnostic tests that rely on detection of antibody to HIV virus are not reliable in infants and young children because of the persistence of transplacentally acquired maternal antibody. For this reason, more sophisticated and often more expensive testing is necessary to diagnose HIV infection in this population.
This topic reviews the strategy for diagnosing HIV infection in infants and young children of mothers with known HIV infection or of uncertain HIV serostatus. The diagnosis of HIV infection in adults and older children (older than age 18 months) and strategies for screening during pregnancy to prevent mother-to-child transmission (MTCT) of HIV are discussed separately:To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- NEED FOR EARLY DIAGNOSIS
- DIAGNOSTIC TESTS
- HIV DNA PCR testing
- HIV RNA assays
- Other tests
- DIAGNOSTIC STRATEGIES
- Maternal HIV status unknown
- HIV-infected mother
- Presumptive exclusion of HIV infection
- Definitive exclusion of HIV infection
- DIAGNOSIS IN CHILDREN OLDER THAN 18 MONTHS
- SOCIETY GUIDELINE LINKS
- SUMMARY AND RECOMMENDATIONS