Dermoscopy of mucosal lesions
- Andreas Blum, MD, MSc
Andreas Blum, MD, MSc
- Associate Professor of Dermatology - Faculty of Medicine
- University of Tuebingen, Germany
- Olga Simionescu, MD, PhD
Olga Simionescu, MD, PhD
- Professor and Head, 1st Clinic of Dermatology
- Carol Davila University of Medicine and Pharmacy
- Giuseppe Argenziano, MD
Giuseppe Argenziano, MD
- Associate Professor and Coordinator of the Skin Cancer Unit
- Arcispedale S. Maria Nuova IRCCS, Reggio Emilia
Dermoscopy, also called dermatoscopy or epiluminescence microscopy, is a noninvasive technique performed using a handheld instrument called a dermatoscope. Dermoscopy is widely used for the examination of pigmented and nonpigmented lesions of the skin, scalp, nails, palms, and soles. It increases the clinician's diagnostic accuracy and may allow the recognition of malignant skin tumors at an early, curable stage [1-6].
There is increasing evidence that dermoscopy may also be helpful for formally trained clinicians to differentiate benign from malignant or suspicious lesions arising in the mucosa and decide whether or not a lesion should be biopsied [7-9]. This topic will review the dermoscopic features of pigmented and nonpigmented mucosal lesions and the dermoscopic criteria for differentiating benign from malignant tumors. The principles of dermoscopy and the dermoscopic evaluation of skin lesions, facial lesions, and lesions of the palms and soles are discussed elsewhere.
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- Argenziano G, Soyer HP, Chimenti S, et al. Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. J Am Acad Dermatol 2003; 48:679.
- Kittler H, Pehamberger H, Wolff K, Binder M. Diagnostic accuracy of dermoscopy. Lancet Oncol 2002; 3:159.
- Menzies SW, Kreusch J, Byth K, et al. Dermoscopic evaluation of amelanotic and hypomelanotic melanoma. Arch Dermatol 2008; 144:1120.
- Ronger S, Touzet S, Ligeron C, et al. Dermoscopic examination of nail pigmentation. Arch Dermatol 2002; 138:1327.
- Stanganelli I, Argenziano G, Sera F, et al. Dermoscopy of scalp tumours: a multi-centre study conducted by the international dermoscopy society. J Eur Acad Dermatol Venereol 2012; 26:953.
- Saida T, Miyazaki A, Oguchi S, et al. Significance of dermoscopic patterns in detecting malignant melanoma on acral volar skin: results of a multicenter study in Japan. Arch Dermatol 2004; 140:1233.
- Lin J, Koga H, Takata M, Saida T. Dermoscopy of pigmented lesions on mucocutaneous junction and mucous membrane. Br J Dermatol 2009; 161:1255.
- Ronger-Savle S, Julien V, Duru G, et al. Features of pigmented vulval lesions on dermoscopy. Br J Dermatol 2011; 164:54.
- Blum A, Simionescu O, Argenziano G, et al. Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction: results of a multicenter study by the International Dermoscopy Society (IDS). Arch Dermatol 2011; 147:1181.
- Jaimes N, Halpern AC. Practice Gaps. Examination of genital area: comment on "Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction". Arch Dermatol 2011; 147:1187.
- Blum A. [Who examines the oral mucosa during the total body skin examination?]. Hautarzt 2012; 63:899.
- Kopf A, personal communication.
- Winning TA, Townsend GC. Oral mucosal embryology and histology. Clin Dermatol 2000; 18:499.
- Farage MA, Maibach HI. Morphology and physiological changes of genital skin and mucosa. Curr Probl Dermatol 2011; 40:9.
- Kittler H. Dermatoscopy: Introduction of a new algorithmic method based on pattern analysis for diagnosis of pigmented skin lesions. Dermatol Pract Concept 2007; 13:3.
- Kittler H, Riedl E, Rosendahl C, Cameron A. Dermatoscopy of unpigmented lesions of the skin: a new classification of vessel morphology based on pattern analysis. Dermatol Pract Concept 2008; 14:4.
- Blum A, Metzler G, Hofmann-Wellenhof R, et al. [Correlation between dermoscopy and histopathology in pigmented and non-pigmented skin tumours]. Hautarzt 2003; 54:279.
- Soyer HP, Kenet RO, Wolf IH, et al. Clinicopathological correlation of pigmented skin lesions using dermoscopy. Eur J Dermatol 2000; 10:22.
- Simionescu O, Dumitrescu D, Costache M, Blum A. Dermatoscopy of an invasive melanoma on the upper lip shows possible association with Laugier-Hunziker syndrome. J Am Acad Dermatol 2008; 59:S105.
- Longo C, Scope A, Lallas A, et al. Blue lesions. Dermatol Clin 2013; 31:637.
- Blum A. [Pigmented lesion at base of tongue: mucosal melanoma or amalgam tattoo?]. Hautarzt 2014; 65:349.
- Scherer P, Fries J, Mischkowski RA, et al. Intraoral molluscum contagiosum imitating a squamous-cell carcinoma in an immunocompetent person--case report and review of the literature. Int J Oral Maxillofac Surg 2009; 38:802.
- Blum A, Kittler H, Zalaudek I, et al. [Unclear clinical change on the glans penis leads to different dermoscopic diagnoses]. Hautarzt 2013; 64:768.
- Cameron A, Rosendahl C, Tschandl P, et al. Dermatoscopy of pigmented Bowen's disease. J Am Acad Dermatol 2010; 62:597.
- Tschandl P, Rosendahl C, Kittler H. Cutaneous human papillomavirus infection: manifestations and diagnosis. Curr Probl Dermatol 2014; 45:92.
- Blum A, Hofmann-Wellenhof R, Luedtke H, et al. Value of the clinical history for different users of dermoscopy compared with results of digital image analysis. J Eur Acad Dermatol Venereol 2004; 18:665.
- EXAMINATION OF MUCOSAL SURFACES
- HISTOLOGY OF MUCOSA AND MUCOCUTANEOUS TRANSITION ZONE
- DERMOSCOPIC FEATURES OF MUCOSAL LESIONS
- Dermoscopic-pathologic correlation
- BENIGN LESIONS
- Melanotic macule
- Acquired melanocytic nevi
- Congenital nevi
- Hemangioma and angiokeratoma
- Amalgam tattoo
- Infectious diseases
- - Molluscum contagiosum
- - Oral papilloma
- Inflammatory diseases
- MALIGNANT LESIONS
- Bowen disease
- - Bowenoid papulosis
- DIAGNOSTIC CRITERIA
- INDICATIONS FOR BIOPSY
- INDICATION FOR DERMOSCOPIC FOLLOW-UP
- SUMMARY AND RECOMMENDATIONS