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Cystic fibrosis: Antibiotic therapy for chronic pulmonary infection

Author
Richard H Simon, MD
Section Editor
George B Mallory, MD
Deputy Editor
Alison G Hoppin, MD

INTRODUCTION

Cystic fibrosis (CF) is a multisystem disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, located on chromosome 7 [1]. (See "Cystic fibrosis: Genetics and pathogenesis".)

Pulmonary disease remains the leading cause of morbidity and mortality in patients with CF [2-5]. One of the major drivers of CF lung disease is infection [6,7]. The approach to treating infection in CF is multifaceted, involving antibiotics, chest physiotherapy, inhaled medications to promote secretion clearance, and anti-inflammatory agents. Undoubtedly, improved use of antibiotics is responsible for a substantial portion of the increased survival that has occurred in patients with CF (figure 1) [4,6].

The use of antibiotics to treat chronic pulmonary infections in CF will be reviewed here. Treatment of acute pulmonary exacerbations and other aspects of pulmonary disease in CF are discussed in separate topic reviews:

(See "Cystic fibrosis: Treatment of acute pulmonary exacerbations".)

(See "Cystic fibrosis: Overview of the treatment of lung disease".)

                              

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Literature review current through: Jul 2017. | This topic last updated: Jun 27, 2017.
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