Cutaneous B cell pseudolymphomas
- Rein Willemze, MD
Rein Willemze, MD
- Professor and Chairman, Department of Dermatology
- Leiden University Medical Center
The term cutaneous pseudolymphoma refers to a heterogeneous group of benign skin disorders that simulate cutaneous lymphomas histologically and sometimes clinically. Cutaneous pseudolymphomas can be separated into two major subtypes, pseudolymphomas mimicking a cutaneous B cell lymphoma (B cell pseudolymphomas) and pseudolymphomas mimicking a cutaneous T cell lymphoma (T cell pseudolymphomas) (table 1) [1-3].
Cutaneous B cell pseudolymphomas (previously called lymphadenosis benigna cutis, lymphocytoma cutis, pseudolymphoma of Spiegler-Fendt, or cutaneous lymphoid hyperplasia) represent a reactive B-cell proliferation response to a variety of antigenic stimuli, including arthropod bites, gold pierced earrings, tattoo dyes, and drugs. They usually present as erythematous nodules or plaques that simulate indolent primary cutaneous B cell lymphomas, in particular primary cutaneous marginal zone lymphoma (PCMZL) or primary cutaneous follicle center lymphoma (PCFCL).
This topic will discuss the pathogenesis, clinical presentation, and differential diagnosis of B cell pseudolymphomas. Primary cutaneous B cell lymphomas, cutaneous T cell pseudolymphomas, and lymphomatoid papulosis are discussed separately.
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- ETIOLOGY AND PATHOGENESIS
- CLINICAL PRESENTATION
- Clinical course
- Clonality analysis
- DIFFERENTIAL DIAGNOSIS
- Primary cutaneous marginal zone lymphoma
- - Are cutaneous B cell pseudolymphoma and PCMZL a disease spectrum?
- Primary cutaneous follicle center lymphoma
- Secondary cutaneous follicular lymphoma
- SUMMARY AND RECOMMENDATIONS