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Medline ® Abstract for Reference 93

of 'Convulsive status epilepticus in adults: Treatment and prognosis'

Prolongation of midazolam half-life after sustained infusion for status epilepticus.
Naritoku DK, Sinha S
Neurology. 2000;54(6):1366.
Midazolam clearance was examined in two patients with medically refractory convulsive status epilepticus. One patient received a constant infusion of midazolam for 68 hours and the other patient received a constant infusion of midazolam for 148 hours. In both patients the decline in level was, overall, much slower than expected. The half-lives of the terminal phase were longer than typically published (52.9 hours in Patient 1 and 20.1 hours in Patient 2). Thus, the data suggest that midazolam exhibits use-dependent pharmacokinetic changes that may be important clinically in situations that require prolonged midazolam therapy.
Department of Neurology, Southern Illinois University, Springfield 62794-9637, USA.