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Medline ® Abstract for Reference 44

of 'Convulsive status epilepticus in adults: Treatment and prognosis'

Intravenous valproate in status epilepticus.
Hodges BM, Mazur JE
Ann Pharmacother. 2001;35(11):1465.
OBJECTIVE: To evaluate the role of intravenous valproate sodium (IV VPA) in the treatment of status epilepticus (SE).
DATA SOURCES: A literature search of the English language was performed (MEDLINE 1966-July 2000). Search terms included valproate, valproic acid, and status epilepticus. Bibliographies of articles chosen were reviewed to identify other possible sources.
DATA SYNTHESIS: A review of the medical literature was conducted to evaluate the safety and efficacy of IV VPA in the treatment of SE.
CONCLUSIONS: Experience with IV VPA in the treatment of SE is too limited to recommend its use as a first-line agent. IV VPA may represent a third- or fourth-line option in cases of SE when other agents are ineffective or contraindicated.
Department of Clinical Pharmacy, School of Pharmacy, West Virginia University, Morgantown, USA.