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Medline ® Abstract for Reference 115

of 'Convulsive status epilepticus in adults: Treatment and prognosis'

Resective surgery to treat refractory status epilepticus in children with focal epileptogenesis.
Alexopoulos A, Lachhwani DK, Gupta A, Kotagal P, Harrison AM, Bingaman W, Wyllie E
Neurology. 2005 Feb;64(3):567-70.
Prolonged high-dose suppressive therapy (HDST) is a mainstay in the management of refractory status epilepticus (RSE), albeit with high morbidity and mortality. The authors studied 10 patients who were carefully selected for epilepsy surgery after failing prolonged (>2 weeks) HDST. Status epilepticus was stopped acutely in all of them with no mortality and no substantial morbidity. At follow-up (median 7 months), 7 (70%) of 10 patients were seizure free, and 3 (30%) of 10 had significant improvement in their epilepsy.
Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.