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Medline ® Abstract for Reference 41

of 'Comorbid disease in psoriasis'

Analysis of cardiovascular risk factors and metabolic syndrome in korean patients with psoriasis.
Kim GW, Park HJ, Kim HS, Kim SH, Ko HC, Kim BS, Kim MB, Sim EK
Ann Dermatol. 2012 Feb;24(1):11-5. Epub 2012 Feb 02.
BACKGROUND: In previous studies, psoriasis has been reported to be associated with metabolic syndrome.
OBJECTIVE: The purpose of this study was to evaluate risk factors for metabolic syndrome in psoriasis patients and to compare the prevalence of metabolic syndrome in psoriasis and control groups.
METHODS: All patients (n=490) and controls (n=682) were investigated for cardiovascular risk factors, including central obesity, hypertension, fasting plasma glucose levels, and blood levels of triglycerides and high-density lipoprotein (HDL).
RESULTS: We found no statistical association between psoriasis and the prevalence of metabolic syndrome when controlling for age and gender. Among individual components of metabolic syndrome, only increased triglyceride levels was significantly prevalent in patients psoriasis. The incidence of other factors such as central obesity, hypertension, fasting plasma glucose and HDL in the psoriasis group were similar to or lower thanthose in the control group. Although psoriasis patients with metabolic syndrome had severe and large plaque-type psoriasis, the association of metabolic syndrome with the severity or clinical subtype of psoriasis was not significant after adjusting for age and gender.
CONCLUSION: Our results suggest that there is no close correlation between psoriasis and metabolic syndrome in Korean patients.
Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea.