Ten patients with recurrent attacks of pseudogout were followed for 1 year before and 1 year after receiving oral colchicine 0.6 mg BID. Thirty-two episodes of acute arthritis were recorded in the year (3.2/patient/year) before the start of the drug and only 10 while taking the drug (1/patient/year) (p less than 0.001). Ninety percent of the patients benefitted from the drug. Our study supports the effectiveness of oral colchicine as a prophylactic agent in recurring pseudogout.