- E William St Clair, MD
E William St Clair, MD
- Professor of Medicine and Immunology
- Chief, Division of Rheumatology and Immunology
- Duke University Medical Center
- Rex McCallum, MD
Rex McCallum, MD
- Professor of Internal Medicine/Rheumatology
- Associate Dean for Clinical Affairs
- University of Texas Medical Branch at Galveston
Cogan’s syndrome (CS) is a chronic inflammatory disorder that most commonly affects young adults. Clinical hallmarks are interstitial keratitis (IK) and vestibuloauditory dysfunction . Associations between CS and systemic vasculitis, as well as aortitis, also exist [2-4].
The pathology, pathogenesis, clinical manifestations, and treatment of CS will be presented here.
Limited autopsy data derived from temporal bone specimens of patients with Cogan’s syndrome (CS) reveal a range of findings, including [5-7]:
●Lymphocyte and plasma cell infiltration of the spiral ligament
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- Hautefort C, Loundon N, Montchilova M, et al. Mycophenolate mofetil as a treatment of steroid dependent Cogan's syndrome in childhood. Int J Pediatr Otorhinolaryngol 2009; 73:1477.
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- CLINICAL FEATURES
- Ocular disease
- Inner ear disease
- Systemic vasculitis
- Other findings
- DIFFERENTIAL DIAGNOSIS
- Systemic vasculitis
- Ocular disease
- - Anterior ocular inflammation
- - Posterior ocular inflammation
- Inner ear disease
- Vestibular dysfunction
- SOCIETY GUIDELINE LINKS
- SUMMARY AND RECOMMENDATIONS