What to do when patients with epilepsy cannot take their usual oral medications

Pract Neurol. 2017 Jan;17(1):66-70. doi: 10.1136/practneurol-2016-001437. Epub 2017 Jan 10.

Abstract

When people with epilepsy are hospitalised for medical or surgical conditions, they may be unable to take their home antiepileptic drugs (AEDs). Such 'nil by mouth' people with epilepsy require alternative AED regimens to prevent breakthrough seizures. Here, we describe several strategies for maintaining seizure control in patients with epilepsy who have medical or surgical contraindications to their home oral regimens. These strategies include using non-pill oral formulations, using an intravenous formulation of the patient's home AED(s), using a benzodiazepine bridge and/or using alternative intravenous AED(s) when there are no intravenous formulations.

Keywords: ANTIEPILEPTIC DRUGS; EPILEPSY; INPATIENT NEUROLOGY.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravenous
  • Administration, Oral
  • Aged, 80 and over
  • Anticonvulsants / administration & dosage*
  • Deglutition / drug effects
  • Deglutition / physiology
  • Epilepsy / diagnosis*
  • Epilepsy / drug therapy*
  • Female
  • Humans
  • Male
  • Middle Aged

Substances

  • Anticonvulsants