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Clinical presentation, initial surgical approach, and prognosis of high-grade gliomas

Author
Jorg Dietrich, MD, PhD
Section Editors
Jay S Loeffler, MD
Patrick Y Wen, MD
Deputy Editor
April F Eichler, MD, MPH

INTRODUCTION

High-grade gliomas are malignant, often rapidly progressive brain tumors that are divided into anaplastic gliomas (anaplastic astrocytoma, anaplastic oligodendroglioma) and glioblastoma based upon their histopathologic and molecular features. (See "Classification and pathologic diagnosis of gliomas", section on 'Histopathologic and molecular classification'.)

The clinical manifestations, prognostic factors, and initial surgical approach to patients with high-grade gliomas will be reviewed here.

Other patient management topics that are covered separately include:

The diagnostic approach to patients with suspected brain tumors (see "Overview of the clinical features and diagnosis of brain tumors in adults")

Adjuvant radiation therapy and chemotherapy following initial surgery (see "Radiation therapy for high-grade gliomas" and "Initial postoperative therapy for glioblastoma and anaplastic astrocytoma")

                           
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Literature review current through: Nov 2017. | This topic last updated: Nov 29, 2017.
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