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Medline ® Abstract for Reference 27

of 'Clinical presentation and diagnosis of non-Hodgkin lymphoma'

Review of contemporaneous mycosis fungoides and B-cell malignancy at Mayo Clinic.
Herro E, Dicaudo DJ, Davis MD, Weaver AL, Swanson DL
J Am Acad Dermatol. 2009;61(2):271.
BACKGROUND: Having either mycosis fungoides or B-cell lymphoma may predispose a patient to the other.
OBJECTIVE: We sought to determine whether the contemporaneous occurrence of the two malignancies is greater than chance and to investigate possible risk factors for the second malignancy.
METHODS: We retrospectively reviewed the records of patients with contemporaneous mycosis fungoides and B-cell lymphoma seen between 1990 and 2007 at Mayo Clinic, Rochester, MN, or at Mayo Clinic, Scottsdale, AZ.
RESULTS: In all, 23 patients had contemporaneous mycosis fungoides and B-cell malignancy. The first diagnosis was mycosis fungoides in 10 patients and B-cell lymphoma in 7; in 6 patients, the diseases were diagnosed simultaneously. No therapeutic factors could account for a predisposition to a second malignancy.
LIMITATIONS: Retrospective design, referral center, and small sample size are limitations.
CONCLUSION: Mycosis fungoides and B-cell lymphoma are unlikely to occur contemporaneously by chance, but no factor obviously predisposes a patient with one malignancy to development of the second.
College of Medicine, Mayo Clinic, Scottsdale, Arizona 85259, USA.