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Medline ® Abstract for Reference 84

of 'Clinical manifestations, pathologic features, and diagnosis of T cell large granular lymphocyte leukemia'

Human leucocyte antigen class I and killer immunoglobulin-like receptor expression patterns in T-cell large granular lymphocyte leukaemia.
Nowakowski GS, Morice WG, Phyliky RL, Li CY, Tefferi A
Br J Haematol. 2005;128(4):490.
T-cell large granular lymphocyte leukaemia (T-LGLL) is often associated with suppression of haematopoiesis through unknown mechanisms. Killer immunoglobulin-like receptors (KIRs) binding human-leucocyte antigen (HLA)-I in an allele-specific manner are frequently expressed by T-LGLL cells. HLA-I genotyping was performed in seven T-LGLL cases in which the neoplastic cells were known to express a single KIR isoform (CD158a, CD158b or CD158e). Five cases showed absence of the cognate HLA-I antigen for the expressed KIR isoform, resulting in KIR/HLA-I 'mismatch'. Cytopenias occurred in all five 'mismatch' patients but not in two patients with 'match', suggesting that KIR/HLA-I mismatch may contribute to the suppression of haematopoiesis.
Department of Hematology, Mayo Clinic, Rochester, MN 55905, USA.