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Medline ® Abstract for Reference 25

of 'Clinical manifestations, pathologic features, and diagnosis of T cell large granular lymphocyte leukemia'

Large granular lymphocytic leukemia presenting late after solid organ transplantation: a case series of four patients and review of the literature.
Kataria A, Cohen E, Saad E, Atallah E, Bresnahan B
Transplant Proc. 2014 Dec;46(10):3278-81. Epub 2014 Sep 18.
Post-transplantation lymphoproliferative disorder (PTLD) is a significant complication of solid organ transplantation. Most PTLD is of the B-cell subtype, although T-cell subtype PTLD uncommonly occurs. T-cell PTLDs are usually aggressive neoplasms and shorten patient and allograft survivals significantly. We present a single-center case series of 4 patients who developed T-cell large granular lymphocytic (LGL) leukemia, a rare T-cell PTLD characterized by large granular lymphocytes that have characteristic azurophilic granules and a highly variable clinical course.
Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: ashkats2003@yahoo.com.