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Medline ® Abstract for Reference 23

of 'Clinical manifestations, pathologic features, and diagnosis of T cell large granular lymphocyte leukemia'

T-cell large granular lymphocytic leukemia following orthotopic liver transplantation.
Feher O, Barilla D, Locker J, Oliveri D, Melhem M, Winkelstein A
Am J Hematol. 1995;49(3):216.
Aggressive T-cell neoplasms are an infrequent complication of allogeneic organ and bone marrow transplantation. To date, chronic T-cell lymphoproliferative malignancies have not been described. The present case documents the occurrence of a T-cell large granular lymphocytic leukemia (T-LGL) in a patient following orthotopic liver transplantation. Genotype studies showed a clonal T-cell receptor beta-chain gene rearrangement. A unique feature was the detection of a specific chromosomal deletion at 1p32 involving the tal-1 gene, an abnormality previously described only in aggressive T-cell neoplasms.
Department of Medicine and Pathology, University of Pittsburgh School of Medicine, Pennsylvania, USA.