Clinical manifestations, pathologic features, and diagnosis of hepatosplenic T cell lymphoma
- Arnold S Freedman, MD
Arnold S Freedman, MD
- Section Editor — Lymphoproliferative Disorders
- Professor of Medicine
- Harvard Medical School
- Jon C Aster, MD
Jon C Aster, MD
- Professor of Pathology
- Harvard Medical School
The peripheral T cell lymphomas (PTCLs) are a heterogeneous group of generally aggressive neoplasms that constitute less than 15 percent of all non-Hodgkin lymphomas (NHLs) in adults. (See "Classification of the hematopoietic neoplasms".)
Among these, in decreasing frequency of occurrence, are:
●Peripheral T cell lymphoma, not otherwise specified (NOS)
●Anaplastic large cell lymphoma, primary systemic type
●Angioimmunoblastic T cell lymphoma
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- CLINICAL FEATURES
- Patterns of involvement
- - Spleen
- - Liver
- - Bone marrow
- Genetic features
- DIFFERENTIAL DIAGNOSIS
- Splenic marginal zone lymphoma
- T cell large granular lymphocyte leukemia
- Aggressive NK leukemia/lymphoma
- Acute lymphoblastic leukemia
- Other gamma/delta lymphomas