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Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)

Arnold S Freedman, MD
Jon C Aster, MD
Section Editor
Andrew Lister, MD, FRCP, FRCPath, FRCR
Deputy Editor
Rebecca F Connor, MD


The non-Hodgkin lymphoma subtype of marginal zone lymphoma represents a group of lymphomas that have been historically classified together because they appear to arise from post-germinal center marginal zone B cells and share a similar immunophenotype: positive for B cell markers CD19, CD20, and CD22, and negative for CD5, CD10, and usually CD23.

Several marginal zone lymphoma subtypes are recognized in the World Health Organization classification of lymphoid neoplasms:

Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT lymphoma)

Nodal marginal zone lymphoma

Splenic marginal zone lymphoma

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Literature review current through: Nov 2017. | This topic last updated: Oct 11, 2017.
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