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Medline ® Abstract for Reference 43

of 'Clinical manifestations and evaluation of spontaneous primary ovarian insufficiency (premature ovarian failure)'

Factors associated with bone density in young women with karyotypically normal spontaneous premature ovarian failure.
Leite-Silva P, Bedone A, Pinto-Neto AM, Costa JV, Costa-Paiva L
Arch Gynecol Obstet. 2009 Aug;280(2):177-81. Epub 2008 Dec 23.
OBJECTIVE: To evaluate bone density and associated factors in women with premature ovarian failure (POF) compared to age-matched women with normal ovarian function.
METHODS: A cross-sectional study of 50 patients with POF undergoing bone mineral densitometry was conducted, compared to 50 women paired by age who menstruated regularly.
RESULTS: In women with POF, the mean bone mineral density measured was 1.22 g/cm(2) at the spine and 0.92 g/cm(2) at the femur, values which were significantly lower than in the control group (P<0.0001). Factors directly associated with bone density of the lumbar spine were age and with bone density of the femur were BMI and reproductive age.
CONCLUSION: Young women with POF have a decrease in lumbar spine and femoral bone density. Age, reproductive age and BMI were the factors associated with BMD. These women need early investigation and treatment to prevent bone loss and minimize fracture risk in the future.
Departament of Obstetrics and Gynaecology, School of Medicine, State University of Campinas, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, Brazil.