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Clinical manifestations and diagnosis of osteoarthritis

Michael Doherty, MA, MD, FRCP, FHEA
Abhishek Abhishek, MBBS, MD, MRCP, PhD
Section Editor
David Hunter, MD, PhD
Deputy Editor
Monica Ramirez Curtis, MD, MPH


Osteoarthritis (OA) is the commonest form of arthritis and possesses marked variability of disease expression. Although most patients present with joint pain and functional limitations [1], the age of disease onset, sequence of joint involvement, and disease progression varies from person to person. OA ranges from an asymptomatic, incidental finding on clinical and/or radiographic examination to a rapidly progressive disabling disorder eventually culminating in "joint failure."

The clinical features and approach to the diagnosis of OA will be reviewed here. The pathogenesis, epidemiology, and treatment of OA are discussed separately. (See "Pathogenesis of osteoarthritis" and "Risk factors for and possible causes of osteoarthritis".)


The primary symptoms of osteoarthritis (OA) are joint pain, stiffness, and locomotor restriction. Symptoms usually present in just one or a few joints in a middle-aged or older person. Other manifestations in patients with OA include sequelae such as muscle weakness and poor balance [2] and comorbidities like fibromyalgia [3-6].

Symptoms and signs — The following symptoms and signs may be observed in patients with OA:

Pain Pain in OA is worse with joint use (usage-related pain) and relieved by rest. It is often the most frequent symptom and generally progresses through three stages [7]:

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Literature review current through: Nov 2017. | This topic last updated: Oct 30, 2017.
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